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Safety Information

T81108

Sigma-Aldrich

1,3,5-Trioxane

≥99%

Synonym(s):

Metaformaldehyde, Trioxymethylene, sym.-Trioxane

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About This Item

Empirical Formula (Hill Notation):
C3H6O3
CAS Number:
110-88-3
Molecular Weight:
90.08
Beilstein:
102769
EC Number:
203-812-5
MDL number:
MFCD00006563
UNSPSC Code:
12352100
PubChem Substance ID:
24900501
NACRES:
NA.22

Quality Level

200

Assay

≥99%

autoignition temp.

777 °F

expl. lim.

29 %

mp

59-62 °C (lit.)

SMILES string

C1OCOCO1

InChI

1S/C3H6O3/c1-4-2-6-3-5-1/h1-3H2

InChI key

BGJSXRVXTHVRSN-UHFFFAOYSA-N

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Application

1,3,5-Trioxane is widely used as a source of anhydrous formaldehyde.
It can be used to synthesize:
  • Polyoxymethylene and hyperbranched polyesters.
  • Calixarenes such as calix[4]resorcinarene, calix[6]resorcinarene and para-tert-butylcalix[8] and [9]arene.
  • Various natural products including (−)-motuporin, (+)-sundiversifolide, (+)-lyconadin A and (−)-lyconadin B.

Signal Word

Danger

Hazard Statements

H228,H335,H361d

Hazard Classifications

Flam. Sol. 1 - Repr. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

4.1B - Flammable solid hazardous materials

WGK

WGK 1

Flash Point(F)

113.0 °F - closed cup

Flash Point(C)

45 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

T81108-25G:
T81108-2KG:
T81108-VAR:
T81108-5G:
T81108-500G:
T81108-100G:
T81108-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hexahydro?1, 3, 5?tripropionyl?s?triazine.
Teeters WO and Gradsten MA.
Organic Syntheses, 51-51 (2003)
The Lyconadins: enantioselective total syntheses of (+)-lyconadin A and (−)-lyconadin B.
Beshore DC and Smith AB.
Journal of the American Chemical Society, 130(41), 13778-13789 (2008)
Single step synthesis of peripherally ?clickable? hyperbranched polyethers.
Saha A and Ramakrishnan S.
Macromolecules, 42(14), 4956-4959 (2009)
Enantioselective synthesis of the protein phosphatase inhibitor (−)-motuporin.
Hu T and Panek JS.
Journal of the American Chemical Society, 124(38), 11368-11378 (2002)
Generation of orthorhombic polyoxymethylene in a cationic polymerization system of trioxane.
Iguchi M.
Polymer, 24(7), 915-920 (1983)
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