Acid-dPEG25-NHS ester is an amine-reactive crosslinker designed to facilitate intermolecular crosslinking with free amines at each end of the crosslinker through a single molecular weight, discrete polyethylene glycol (dPEG) backbone. The correct use of this product eliminates intramolecular crosslinking. The dPEG backbone is amphiphilic. Consequently, it imparts water solubility to molecules to which it is conjugated. The dPEG spacer is 79 atoms (92.5 Å) long. The dPEG spacer in this product is the monodisperse PEG equivalent of PEG1000. One end of the chain terminates in a propionic acid group. The other end terminates as the N-hydroxysuccinimidyl (NHS) ester of propionic acid. While both ends of the molecule can react with free amines such as the ε-amine group of lysine, only one end of the dPEG spacer is activated as the NHS ester. This construction permits only one end of the spacer to react at a time, thus giving the user greater control over crosslinking molecules using this product.
Legal Information
Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
JAN Code
QBD10140-100MG:
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Lot/Batch Number
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