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Safety Information

N162

Sigma-Aldrich

R-(−)-Niguldipine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C36H39N3O6 · HCl
CAS Number:
113145-70-3
Molecular Weight:
646.17
MDL number:
MFCD00905004
UNSPSC Code:
12352005
PubChem Substance ID:
329818586

optical activity

[α]23/D −12.5°, c = 0.14 in methanol(lit.)

color

pale yellow

solubility

methanol: soluble

storage temp.

−20°C

SMILES string

Cl.COC(=O)C1=C(C)NC(C)=C([C@@H]1c2cccc(c2)[N+]([O-])=O)C(=O)OCCCN3CCC(CC3)(c4ccccc4)c5ccccc5

InChI

1S/C36H39N3O6.ClH/c1-25-31(34(40)44-3)33(27-12-10-17-30(24-27)39(42)43)32(26(2)37-25)35(41)45-23-11-20-38-21-18-36(19-22-38,28-13-6-4-7-14-28)29-15-8-5-9-16-29;/h4-10,12-17,24,33,37H,11,18-23H2,1-3H3;1H/t33-;/m1./s1

InChI key

MHOSUIMBPQVOEU-MGDILKBHSA-N

Biochem/physiol Actions

Less active enantiomer

Caution

Photosensitive. Adsorbs strongly to plastic.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

N162-VAR:
N162-BULK:
N162-5MG:

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V Höllt et al.
Biochemical pharmacology, 43(12), 2601-2608 (1992-06-23)
The (-)-isomer of verapamil is 10-fold more potent as a calcium antagonist than the (+)-isomer. However, both enantiomers are equally effective in increasing cellular accumulation of anticancer drugs [Gruber et al., Int J Cancer 41: 224-226, 1988]. In addition to

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