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Drug development and industrial pharmacy, 24(3), 225-233 (1999-01-07)
In this study, acetaminophen, ascorbic acid, and ethenzamide were selected as model drugs for tableting granules. Agitation and fluidized-bed granulation were carried out at three drug contents of 30, 50, and 70%. Compared with agitation granulation, granules made by fluidized-bed
Journal of magnetic resonance (San Diego, Calif. : 1997), 202(2), 135-139 (2009-11-11)
An efficient method to separate the (13)C NMR spectra of solid mixtures is introduced. The (1)H longitudinal (T(1)) relaxation time is used to separate the overlapping (13)C chemical shift spectra of solid mixtures via an inverse Laplace transform (ILT) of
International journal of pharmaceutics, 441(1-2), 135-145 (2012-12-19)
The objective of this study was to evaluate the high shear granulation process using near-infrared (NIR) chemical imaging technique and to make the findings available for pharmaceutical development. We prepared granules and tablets made under appropriate- and over-granulation conditions with
International journal of pharmaceutics, 311(1-2), 89-96 (2006-01-24)
Ethenzamide solids as a representative active pharmaceutical ingredient (API) were batch-ground by means of a fluidized-bed jet-mill which is a relatively new equipment and promising for production in the pharmaceutical field. Thus, the characteristic grinding mechanism was investigated. As a
International journal of pharmaceutics, 532(1), 82-89 (2017-09-02)
In this study, we evaluated the correlation between the response surfaces for the tablet characteristics of placebo and active pharmaceutical ingredient (API)-containing tablets. The quantities of lactose, cornstarch, and microcrystalline cellulose were chosen as the formulation factors. Ten tablet formulations
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