CAR-214

Cardiolipin Liposomes

PC:CL (5:95 molar ratio 10mM)

• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• Quality Level: 100
• composition: Phosphate buffered saline
• concentration: 10 mM
• impurities: 5 mol % L-alpha-phosphatidylcholine (PC); 95 mol % Cardiolipin (CL)
• particle size: 100 nm
• pH: 7.4

Description

General description

Liposomes are extensively used to study the interaction of proteins, peptides and other molecules with the surface of a lipid membrane.

Cardiolipin (CL) is a unique phospholipid with an interesting chemical and ultrastructural characteristics. It is a highly acidic dimer of phosphatidylglycerol (PG) and phosphatidic acid (PA) containing four acyl chains, three glycerols and two phosphate headgroups. Due to deprotonation of one of these phosphate groups, cardiolipin is negatively charged in physiological pH.

Cardiolipin (CL) is known as a mitochondria-specific phospholipid and is intimately linked to mitochondrial bioenergetic processes. It plays a functional role in mitochondrial membrane stability and dynamics, as it interacts with a number of inner mitochondrial membrane metabolite carriers, enzymes and proteins. Extensive studies of phamacological, toxicological, and therapeutic effects have shown that the incorporation of doxorubicin in cardiolipin liposomes improved antitumor activity. It has been reported that cardiolipin-containing liposomes have lower cardiotoxicity associated with doxorubicin by alteriing the pharmacokinetics and tissue distribution of the drug.

Cardiolipin is a negatively charged lipid and provides two types of binding possibilities: binding at the surface and encapsulation deep within the membrane. Our catalog of cardiolipin lipids contains many different types of saturated and unsaturated cardiolipin based liposomes made from 0.5% up to 100% cardiolipin.

Application

Drug delivery
Lipid-protein interactions

Storage and Stability

Liposomes should never be frozen. Liposomes should be stored in the dark at 4°C, except when brought to room temperature for brief periods prior to use.

Liposomes are made under sterile conditions. If you need to take multiple aliquots out of the vial, it is advised to take extreme care in not contaminating the vial. It is recommended to handle the vial under a sterile hood to maintain the sterility of the product. Liposomes should never be frozen. Ice crystals that form during freezing will rupture the lipid membrane of the liposomes and change the size of liposomes particles.

Legal Information

Cellsome is a trademark of Encapsula NanoSciences

Product of Encapsula Nanosciences

Disclaimer

For research use only

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable