Skip to Content
Merck
All Photos(2)

Documents

Safety Information

C85778

Sigma-Aldrich

o-Cresolphthalein

Indicator grade, powder

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Empirical Formula (Hill Notation):
C22H18O4
CAS Number:
596-27-0
Molecular Weight:
346.38
Beilstein:
310554
EC Number:
209-881-8
MDL number:
MFCD00005912
UNSPSC Code:
12171500
PubChem Substance ID:
24893078
NACRES:
NA.47

product name

o-Cresolphthalein, indicator grade

grade

indicator grade

form

powder

technique(s)

titration: suitable

color

beige

pH

8.2-9.8, colorless to red

mp

219-221 °C (lit.)

λmax

381 nm (2nd)
566 nm

ε (extinction coefficient)

≥10000 at 294-300 nm
≥39000 at 564-570 nm
≥5000 at 378-384 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

Cc1cc(ccc1O)C2(OC(=O)c3ccccc23)c4ccc(O)c(C)c4

InChI

1S/C22H18O4/c1-13-11-15(7-9-19(13)23)22(16-8-10-20(24)14(2)12-16)18-6-4-3-5-17(18)21(25)26-22/h3-12,23-24H,1-2H3

InChI key

CPBJMKMKNCRKQB-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

O-Cresolphthalein has been used as a component in calcifying media for calcification assay.

Biochem/physiol Actions

o-Cresolphthalein is a reversible pH indicator. The kinetics of the reverse pathway (red-purple to colorless) is slow, thereby making it an appropriate molecule to check flow patterns in ducts with corrugated walls. It is also used for the colorimetric determination of calcium content via the o-cresolphthalein complexone method. Binding of calcium to o-cresolphthalein, in the presence of alkaline conditions (pH 10-12), results in the formation of a red complex with an absorbance at 570-575nm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

C85778-10G:
C85778-1KG:
C85778-VAR:
C85778-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Ali Duran et al.
Journal of hazardous materials, 169(1-3), 466-471 (2009-04-29)
In present study preconcentration followed by solid phase extraction of heavy metal ions, Cu(II), Co(II), Ni(II) and Pb(II) using a multiwalled carbon nanotubes (MWNTs) and complexing reagent o-cresolphthalein complexone were investigated. The effects of parameters, including pH of the solutions
Jin-Hyun Kim et al.
PloS one, 14(4), e0215244-e0215244 (2019-04-17)
In the stratum corneum, the intercellular junction made up of cadherin proteins provides the structural integrity of the framework. Ca2+ ions are known to play a key role in maintaining this junction. In this study, we hypothesized that Ca2+ chelation
Natalia Campos-Obando et al.
European journal of epidemiology (2018-05-17)
Hyperphosphatemia has been associated with increased mortality in chronic kidney disease but the nature of such a relation in the general population is unclear. To investigate the association between phosphate (P) levels and all-cause and cause-specific mortality, we assessed two
Hyunseok Peter Kang et al.
Clinical chemistry, 50(4), 741-746 (2004-02-14)
Gadolinium formulations, which are administered as contrast agents in magnetic resonance imaging examinations, interfere with colorimetric serum calcium determinations. We performed an in vitro study to determine the extent to which three gadolinium formulations-gadodiamide (Omniscan), gadopentetate dimeglumine (Magnevist), and gadoversetamide
Diabetic vascular calcification mediated by the collagen receptor discoidin domain receptor 1 via the Phosphoinositide 3-Kinase/Akt/Runt-related transcription factor 2 signaling axis
Lino M, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 38(8), 1878-1889 (2018)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service