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937754

Sigma-Aldrich

Poly(D,L-lactic-co-glycolic acid)-block-poly(glutamic acid)

PLGA average Mn 25,000, mol wt (PGlu average Mn 5,000), lactide:glycolide 50:50

Synonym(s):

Amphiphilic, Block polymer, Drug delivery, Glutamic acid, PLGA, PLGA-b-PGlu, Poly(glutamic acid), Polyaminoacids

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About This Item

Linear Formula:
[(C3H4O2)a(C2H2O2)b]n O[C5H7NO3]m
UNSPSC Code:
12162002
NACRES:
NA.21

feed ratio

lactide:glycolide 50:50

Quality Level

100

mol wt

PLGA average Mn 25,000
 (PGlu average Mn 5,000)

color

white to beige, powder

storage temp.

−20°C

Related Categories

Application

This polymer is a amphiphilic diblock copolymer composed of a hydrophobic PLGA block and a hydrophilic poly(glutamic acid) block. PLGA is a biocompatible and biodegradable polymer that has been approved by the FDA and the EMA for biomedical and pharmaceutical applications. Poly(glutamic acid) is biodegradable, non-toxic and non-immunogenic macromolecules. This biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, for drug delivery applications

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

937754-100MG:
937754-BULK:
937754-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ibrahim R Khalil et al.
International journal of molecular sciences, 18(2) (2017-02-06)
In the past decade, poly-γ-glutamic acid (γ-PGA)-based micro/nanoparticles have garnered remarkable attention as antimicrobial agents and for drug delivery, owing to their controlled and sustained-release properties, low toxicity, as well as biocompatibility with tissue and cells. γ-PGA is a naturally
Yung-Chih Kuo et al.
Colloids and surfaces. B, Biointerfaces, 88(1), 158-164 (2011-07-19)
Nanoparticles (NPs) with ternary components of polyethyleneimine (PEI), poly-(γ-glutamic acid) (γ-PGA), and poly(lactide-co-glycolide) (PLGA) were applied to carry and release saquinavir (SQV). Hydrophobic SQV was encapsulated in the particle core composed of PLGA to form SQV-PLGA NPs, and the surface

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