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934216

Sigma-Aldrich

NanoFabTx™ - Mannose Lipid Mix

for synthesis of mannose-targeted liposomes

Synonym(s):

Liposome synthesis kit, Small molecule drug formulation kit

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About This Item

UNSPSC Code:
12352211

Quality Level

100

storage temp.

−20°C

Application

NanoFabTx™ Mannose Lipid Mix is a ready-to-use curated lipid mixture containing rationally selected lipids and step by step instructions for synthesizing mannose targeted liposomes.Mannose receptors are over expressed on several cancer cells. Mannose receptors are also over expressed by macrophages, which play a critical role in inflammatory responses. Thus the mannose receptor can be used to achieve targeted delivery of drugs to these cells. The liposomes containing the mannose ligand will be internalized by the cells that over express the mannose receptors. Such a delivery technique will help in achieving targeted delivery of the drugs and avoid off target effects, which is a major side effect of many cancer therapies.

The mannose targeted- liposomes synthesized from the NanoFabTx™ Mannose Lipid Mix enable users to 1) encapsulate a wide variety of small molecules and 2) selectively target cells which overexpress mannose receptors, such as macrophages and certain cancer cells, without the need for lengthy trial-and-error optimization.

Features and Benefits

  • A ready-to-use lipid blend for the synthesis of Mannose targeted liposomes
  • Step-by-step protocols (extrusion, microfluidics) developed and tested by our formulation scientists
  • Flexible synthesis tool to create uniform and reproducible liposomes
  • Mannose ligand enables targeted drug delivery
Comprehensive protocols for liposome synthesis are included:
  • A lipid film hydration and extrusion protocol
  • A microfluidics protocol using commercial platforms or syringe pumps
The microfluidics protocol included with this product uses the NanoFabTx™ device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

For more information, please refer to the protocol under the Protocol section of this page.

Legal Information

NanoFabTx is a trademark of Sigma-Aldrich Co. LLC
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

934216-VAR:
934216-100MG-PW:
934216-25MG-PW:
934216-100MG:
934216-25MG:
934216-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Drug-free mannosylated liposomes inhibit tumor growth by promoting the polarization of tumor-associated macrophages
Ye J, et al.
International journal of nanomedicine, 14, 3203-3220 (2019)
Mannosylated liposomes improve therapeutic effects of paclitaxel in colon cancer models
Xiong M, et al.
Journal of Microencapsulation, 34, 513- 521 (2017)
Mannosylated liposomes for targeted gene delivery
Kong F, et al.
International journal of nanomedicine, 7, 1079-1089 (2012)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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