Skip to Content
Merck
All Photos(1)

Documents

Safety Information

931853

Sigma-Aldrich

SPhos Pd G6 acylation

≥95%

Synonym(s):

(SPhos)Pd(4-CH2CH2CONHSPh)Br

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C39H47BrNO6PPd
CAS Number:
2723495-97-2
Molecular Weight:
843.09
UNSPSC Code:
12352100
NACRES:
NA.21

Quality Level

100

Assay

≥95%

form

powder

reaction suitability

reagent type: catalyst
reaction type: Cross Couplings

Application

SPhos Pd G6 acylation is an oxidative addition complex (OAC) of SPhos for use in bioconjugation. The pendant NHS-functional group allows coupling to protein amines through a selective acylation. The protein-OAC can then be reacted with a second, cysteine-containing protein. This facile approach allows for protein homodimerization as well as the formation of antibody-protein conjugates.

Learn more about G6 Buchwald precatalysts

Other Notes

Palladium–Protein Oxidative Addition Complexes by Amine-Selective Acylation

related product

Product No.
Description
Pricing

912646

tBuBrettPhos Pd G6 bromide

912883

tBuBrettPhos Pd G6 TES

915378

AdBrettPhos Pd G6 Br

915602

AlPhos Pd G6 Br

916455

AlPhos Pd G6 OTf

922900

GPhos Pd G6 TES

925454

AdCyBrettPhos Pd G6 Br

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

931853-VAR:
931853-100MG:
931853-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Muhammad Jbara et al.
Angewandte Chemie (International ed. in English), 60(21), 12109-12115 (2021-03-18)
Organometallic reagents enable practical strategies for bioconjugation. Innovations in the design of water-soluble ligands and the enhancement of reaction rates have allowed for chemoselective cross-coupling reactions of peptides and proteins to be carried out in water. There are currently no
Heemal H Dhanjee et al.
Journal of the American Chemical Society, 142(51), 21237-21242 (2020-12-16)
Palladium oxidative addition complexes (OACs) are traditionally accessed by treating an aryl halide-containing substrate with a palladium(0) source. Here, a new strategy to selectively prepare stable OACs from amino groups on native proteins is presented. The approach relies on an
Ryan P King et al.
Organic letters, 23(20), 7927-7932 (2021-10-07)
The utilization of isolated Palladium Oxidative Addition Complexes (OACs) has had a significant impact on Pd-catalyzed and Pd-mediated cross-coupling reactions. Despite their importance, widespread utility of OACs has been limited by the instability of their precursor complexes. Herein, we report

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service