Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

925624

Sigma-Aldrich

Redox Responsive Poly(ethylene glycol)-block-poly(ε-caprolactone)

PEG average Mn 5,000, PCL Mn 15,000

Synonym(s):

Block copolymer, PEG-PCL with disulfide linkage, PEG-SS-PCL, Stimuli-responsive

Sign Into View Organizational & Contract Pricing

Select a Size

1 G
¥78,800

¥78,800

Check Cart for Availability
Request a Bulk Order
All Photos(1)

Select a Size

Change View
1 G
¥78,800

About This Item

Linear Formula:
CH3O(C2H4O)nC7H12O4S2(C6H10O2)
UNSPSC Code:
12352112
NACRES:
NA.23

¥78,800

Check Cart for Availability
Request a Bulk Order

form

solid (could be powder/granules/chunks)

Quality Level

100

mol wt

PCL Mn 15,000
PEG average Mn 5,000

color

white to beige, light yellow

storage temp.

2-8°C

Related Categories

Application

PEG-SS-PCL is a redox responsive, biocompatible, amphiphilic block copolymer composed of a hydrophilic poly(ethylene glycol) (PEG) block and a hydrophobic poly(ε-caprolactone) (PCL) block, with a reducible disulfide linkage between blocks. This polymer can be fabricated into Glutathione (GSH) responsive nanoparticles which can be used as an intracellular drug delivery system.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

925624-VAR:
925624-1G:
925624-BULK:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCQ9355

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

pH/redox dual-sensitive nanoparticles based on the PCL/PEG triblock copolymer for enhanced intracellular doxorubicin release.
Cao Y, et al.
Royal Society of Chemistry Advances, 5, 28060-28069 (2015)
Philip Grossen et al.
Journal of controlled release : official journal of the Controlled Release Society, 260, 46-60 (2017-05-26)
The lack of efficient therapeutic options for many severe disorders including cancer spurs demand for improved drug delivery technologies. Nanoscale drug delivery systems based on poly(ethylene glycol)-poly(ε-caprolactone) copolymers (PEG-PCL) represent a strategy to implement therapies with enhanced drug accumulation at

Articles

Therapeutic Nanoparticles Harness Myeloid Cells for Brain Tumor-Targeted Delivery and Immunomodulation

Immunosuppressive tumor-associated myeloid cells (TAMC) are responsible for glioblastoma (GBM) resistance to immunotherapies and existing standard of care treatments. This mini-review highlights recent progress in implementing nanotechnology in advancing TAMC-targeted therapies for GBM.

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service