910074

27,27-Dimethyl-25-oxo-3,6,9,12,15,18,26-heptaoxaoctacosanoic acid

≥95%

• Synonym(s): 2-2-2-2-2-2-6 PROTAC^® linker, Bifunctional linker, OtBu-PEG₆-acid
• Empirical Formula (Hill Notation): C₂₃H₄₄O₁₀
• Molecular Weight: 480.59
• UNSPSC Code: 12352106

Properties

• Assay: ≥95%
• form: liquid
• reaction suitability: reagent type: linker
• functional group: carboxylic acid; ester
• storage temp.: 2-8°C
• SMILES string: O=C(CCCCCCOCCOCCOCCOCCOCCOCC(O)=O)OC(C)(C)C

Description

Application

This heterobifunctional, PEGylated crosslinker 27,27-dimethyl-25-oxo-3,6,9,12,15,18,26-heptaoxaoctacosanoic acid features a carboxyl group at one end and a t-butyl protected carboxylic acid at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. The linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or pproteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-2-2-2-2-6.

Other Notes

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Partial PROTACs for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable