Skip to Content
Merck
All Photos(1)

Documents

Safety Information

901546

Sigma-Aldrich

Poly(M(EO)2MA:Poly(OEGMA) 90:10

hydrazide functionalized, 25 wt. % (solution in water)

Synonym(s):

PEGMA-co-POEGMA

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
[CH2CCH3(COO(CH2CH2O)2CH3)]p[CH2CCH3(COO(CH2CH2O)8CH3)]n[CH2CHCONHNHCO(CH2)4CONHNH2]m
UNSPSC Code:
12162002
NACRES:
NA.23

form

solution

mol wt

Mw ~20,000 g/mol

concentration

25 wt. % (solution in water)

color

clear colorless to pale yellow

functional group

hydrazide

storage temp.

2-8°C

Application

In addition, the physical properties of the resulting hydrogels, such as LCST, gelation rates, swelling kinetics, degradation kinetics, and mechanical properties, can all be readily controlled by solution concentration and the ratios of each solution.

This product is provided as a 25 wt% solution in water, ready to be diluted for your specific application. Please see the technical bulletin on the product page for dilution instructions and hydrogel preparation instructions.
Poly(diethylene glycol methacrylate)-co-(oligoethylene glycol methacrylate), (PM(EO)2MA-co-OEGMA) is a comb-shaped, graft copolymer consisting of hydrophilic oligomer polyethylene glycol (PEG) chains grafted to a hydrophobic polymethacrylate backbone. In this material, the PEG chains are either diethylene glycol units or oligomer PEG (n=8-9) units. Resulting material properties can be tuned by controlling the ratio of each component. POEGMA has been suggested as a viable alternative to PEG in biological and biomaterial applications. POEGMA has been reported to improve pharmacokinetic properties of protein and peptide conjugates, enhance the stability and gene silencing efficiency of siRNAs, as an anti-fouling surface for biosensors, and eliminate PEG antigenicity. In addition to use in biomolecule-polymer conjugates, PEOGMA has also seen wide spread use in tissue engineering applications, such as hydrogel synthesis. Hydrazide-functionalized PM(EO)2MA-co-OEGMA can be readily used with the corresponding aldehyde-functionalized POEGMA or PM(EO)2MA-co-OEGMA for rapid gelation via reversible hydrazone bond formation. Due to the reversibility of the bond formation and the low viscosity of the precursors, resulting hydrogels can be used as injectable tissue engineering matrices, local drug delivery vehicles for small molecules, or as joint lubricants.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

901546-1G:
901546-VAR:
901546-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A brush-polymer/exendin-4 conjugate reduces blood glucose levels for up to five days and eliminates poly(ethylene glycol) antigenicity.
Qi Y, et al.
Nature Biomedical Engineering, 1, 0002-0002 (2016)
Reactive electrospinning of degradable poly(oligoethylene glycol methacrylate)-based nanofibrous hydrogel networks.
Xu F, et al.
Chemical Communications (Cambridge, England), 52, 1451-1454 (2016)
?Off-the-shelf? thermoresponsive hydrogel design: tuning hydrogel properties by mixing precursor polymers with different lower-critical solution temperatures.
Bakaic E, et al.
Royal Society of Chemistry Advances, 5, 33364-33376 (2015)
Injectable hydrogels based on poly(ethylene glycol) and derivatives as functional biomaterials.
Bakaic E, et al.
Royal Society of Chemistry Advances, 5, 35469-35486 (2015)
Weiping Gao et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(36), 15231-15236 (2009-08-27)
The challenge in the synthesis of protein-polymer conjugates for biological applications is to synthesize a stoichiometric (typically 1:1) conjugate of the protein with a monodisperse polymer, with good retention of protein activity, significantly improved pharmacokinetics and increased bioavailability, and hence
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service