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76153

Sigma-Aldrich

PEGA resin

extent of labeling: ~0.4 mmol/g loading

Synonym(s):

Poly[acryloyl-bis(aminopropyl)polyethylene glycol]

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1 G
¥22,300

¥22,300

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1 G
¥22,300

About This Item

MDL number:
MFCD00165212
UNSPSC Code:
23151817
NACRES:
NA.22

¥22,300

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Request a Bulk Order

product line

PEGA

Quality Level

100

form

crystals

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

extent of labeling

~0.4 mmol/g loading

impurities

90% methanol

particle size

150-300 μm

functional group

amine

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General description

PEGA resins are a hydrophilic acrylamide-PEG co-polymer providing a really extensive and more uniform swelling in a wide range of solvents (from water, methanol, ethanol to tetrahydrofuran, acetonitrile and toluene). The extreme swelling volume of this support in the standard peptide synthesis solvents DCM and DMF together with their good stability make them ideally suited for the batch as well as for continuous-flow syntheses.

Application

Polyacrylamide resin possessing long polyethylene glycol spacers giving extremely high swell resin may be used for:
  • immobilizing enzymes in aqueous solution[1]
  • affinity purification of small-molecule binding proteins[2]
  • synthesis of peptide libraries with fluorescently labeled proteins[3]

Packaging

Sold on basis of weight of dry resin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

76153-1G:
76153-VAR:
76153-BULK:
76153-5G:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM8662
BCBP4861V
1381725V
1381725
1313432

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N,N′-Methylenebis(acrylamide) 99%

Sigma-Aldrich

146072

N,N′-Methylenebis(acrylamide)

Catch and release of concanavalin A by a mannose-immobilized photoaffinity PEGA resin coupled with a cleavable disulfide linker.
Kuramochi K, et al.
Bioscience, Biotechnology, and Biochemistry, 79(12), 1946-1953 (2015)
PEGA supports for combinatorial peptide synthesis and solid-phase enzymatic library assays.
Renil M, et al.
Journal of Peptide Science, 4(3), 195-195 (1998)
Large scale modification of biomolecules using immobilized sortase A from Staphylococcus aureus
Steinhagen M, et al.
Bioorganic & Medicinal Chemistry, 21(12), 3504-3510 (2013)
A PEGA resin for use in the solid-phase chemical?enzymatic synthesis of glycopeptides.
Meldal M, et al.
Journal of the Chemical Society. Chemical Communications, 16, 1849-1850 (1994)
Synthesis, characterization and biocompatibility of PEGA resins.
Auzanneau FI, et al.
Journal of Peptide Science, 1(1), 31-44 (1995)
View All Related Papers

Related Content

Acrylamide-PEG Co-polymer (“PEGA”) Resin

The high swelling volume of PEGA resins makes the functionalities located within the polymer bead accessible to large biomolecules.

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