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739588

Sigma-Aldrich

Potassium 2-methoxypyrimidin-5-yl-5-trifluoroborate

90%

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About This Item

Empirical Formula (Hill Notation):
C5H5BF3KN2O
CAS Number:
1111732-99-0
Molecular Weight:
216.01
MDL number:
MFCD09993118
UNSPSC Code:
12352103
PubChem Substance ID:
329765360
NACRES:
NA.22

Assay

90%

form

solid

mp

239-254 °C

SMILES string

[K+].COc1ncc(cn1)[B-](F)(F)F

InChI

1S/C5H5BF3N2O.K/c1-12-5-10-2-4(3-11-5)6(7,8)9;/h2-3H,1H3;/q-1;+1

InChI key

ACPITJHSWGPRRF-UHFFFAOYSA-N

Application

Potassium 2-methoxypyrimidin-5-yl-5-trifluoroborate can be used as a substrate in:
  • Metal-free synthesis of biaryls through oxidative electrocoupling reaction.
  • Cross-coupling reactions with unactivated alkyl halides in the presence of a nickel catalyst.
  • Suzuki-Miyaura coupling with aryl and heteroaryl halides using a palladium catalyst.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

739588-1G:
739588-BULK:
739588-5G:
739588-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Arif Music et al.
Journal of the American Chemical Society, 142(9), 4341-4348 (2020-02-11)
We report herein versatile, transition metal-free and additive-free (hetero)aryl-aryl coupling reactions promoted by the oxidative electrocoupling of unsymmetrical tetra(hetero)arylborates (TABs) prepared from ligand-exchange reactions on potassium trifluoroarylborates. Exploiting the power of electrochemical oxidations, this method complements the existing organoboron toolbox.
Nickel-catalyzed cross-coupling of potassium aryl-and heteroaryltrifluoroborates with unactivated alkyl halides
Molander GA, et al.
Organic Letters, 12(24), 5783-5785 (2010)
Electrochemical Synthesis of Biaryls via Oxidative Intramolecular Coupling of Tetra(hetero)arylborates
Music A, et al.
Journal of the American Chemical Society, 142(9), 4341-4348 (2020)
Scope of the Suzuki- Miyaura cross-coupling reactions of potassium heteroaryltrifluoroborates
Molander GA, et al.
The Journal of Organic Chemistry, 74(3), 973-980 (2009)
Gary A Molander et al.
Organic letters, 12(24), 5783-5785 (2010-11-26)
A method for the cross-coupling of alkyl electrophiles with various potassium aryl- and heteroaryltrifluoroborates has been developed. Nearly stoichiometric amounts of organoboron species could be employed to cross-couple a large variety of challenging heteroaryl nucleophiles. Several functional groups were tolerated
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