Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

593060

Sigma-Aldrich

2,6-Difluoro-4-methoxyphenylboronic acid

≥95%

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C7H7BF2O3
CAS Number:
406482-20-0
Molecular Weight:
187.94
MDL number:
MFCD05664299
UNSPSC Code:
12352103
PubChem Substance ID:
24881327
NACRES:
NA.22

Assay

≥95%

form

solid

mp

125-130 °C (lit.)

functional group

fluoro

SMILES string

COc1cc(F)c(B(O)O)c(F)c1

InChI

1S/C7H7BF2O3/c1-13-4-2-5(9)7(8(11)12)6(10)3-4/h2-3,11-12H,1H3

InChI key

WVSZSFADEBGONQ-UHFFFAOYSA-N

Application

2,6-Difluoro-4-methoxyphenylboronic acid can be used:
  • To prepare a ligand N4Py2Ar2, which in turn is used to synthesize a Fe complex, employed in aromatic C−F hydroxylation reactions.[1]
  • As a substrate in the study of copper-catalyzed trifluoromethylthiolation of boronic acids.[2]
  • As a substrate in the preparation of a thio xylopyranoside as a potent antithrombotic agent.[3]

Reactant involved in Suzuki and Stille coupling reactions for synthesis of antithrombotic drugs

Other Notes

Contains varying amounts of anhydride

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

593060-BULK:
593060-5G:
593060-VAR:
593060-1G:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
SHBD0101V
41696PM
41696PMV
17996PK
14713CJ

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Aromatic C-F Hydroxylation by Nonheme Iron (IV)-Oxo Complexes: Structural, Spectroscopic, and Mechanistic Investigations
Sahu S, et al.
Journal of the American Chemical Society, 138(39), 12791-12802 (2016)
Mild and soft catalyzed trifluoromethylthiolation of boronic acids: the crucial role of water
Glenadel Q, et al.
Chemistry?A European Journal , 21(42), 14694-14698 (2015)
Palladium-catalyzed C-C coupling: efficient preparation of new 5-thio-beta-d-xylopyranosides as oral venous antithrombotic drugs
Bondoux M, et al.
Tetrahedron Letters, 50(27), 3872-3876 (2009)

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service