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Safety Information

55940

Sigma-Aldrich

3-Hydroxy-2-naphthoic hydrazide

≥98.0%

Synonym(s):

3-Hydroxy-2-naphthydrazide

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About This Item

Linear Formula:
HOC10H6CONHNH2
CAS Number:
5341-58-2
Molecular Weight:
202.21
Beilstein:
395153
EC Number:
226-282-7
MDL number:
MFCD00004097
UNSPSC Code:
12352100
PubChem Substance ID:
57651560
NACRES:
NA.22

Quality Level

100

Assay

≥98.0%

mp

205-208 °C (lit.)
205-208 °C

SMILES string

NNC(=O)c1cc2ccccc2cc1O

InChI

1S/C11H10N2O2/c12-13-11(15)9-5-7-3-1-2-4-8(7)6-10(9)14/h1-6,14H,12H2,(H,13,15)

InChI key

FDNAQCWUERCJBK-UHFFFAOYSA-N

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Application

3-Hydroxy-2-naphthoic hydrazide may be used to synthesize the following 2-(alkyl/arylamino)-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazoles:[1]
  • 2-ethylamino-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
  • 2-phenethylamino-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
  • 2-phenylamino-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
  • 2-(p-bromophenylamino)-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
  • 2-(p-chlorophenylamino)-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
  • 2-(p-fluorophenylamino)-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
  • 2-(m-fluorophenylamino)-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
  • 2-(p-methoxyphenylamino)-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
  • 2-(p-methylphenylamino)-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
  • 2-(m-trifluoromethylphenylamino)-5-(3-hydroxy-2-naphthyl)-1,3,4-thiadiazole
It may also be employed for the synthesis of 3-hydroxy-2-naphthaldehyde.[2]

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

55940-BULK:
55940-INTR:
55940-100G:
55940-VAR:
55940-5G:
55940-25G:

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Certificates of Analysis (COA)

Lot/Batch Number
046365/1
037828/1
37828/1
46365/1

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Histochemical demonstration of protein-bound amino groups.
L P WEISS et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2(1), 29-49 (1954-01-01)
A Pompella et al.
The American journal of pathology, 142(5), 1353-1357 (1993-05-01)
Confocal laser scanning fluorescence microscopy plus image videoanalysis was used to visualize the tissue areas and the subcellular sites first involved by oxidative stress and lipid peroxidation, in the well-established experimental model of lipid peroxidation induced by haloalkane intoxication in
Molecular structure, vibrational spectroscopic, first-order hyperpolarizability and HOMO, LUMO studies of 3-hydroxy-2-naphthoic acid hydrazide.
Karpagam J, et al.
Journal of Raman Spectroscopy, 41(1), 53-62 (2010)
Thangaraj Anand et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 17(4), 414-422 (2018-03-06)
An easy to prepare novel vitamin B6 cofactor derivative 3-hydroxy-N'-((3 hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylene)-2-naphthohydrazide (NPY) was synthesized by a one pot condensation reaction of pyridoxal with 3-hydroxy-2-naphthoic hydrazide and applied for the optical detection of Zn2+ and cysteine in the aqueous DMSO medium.
M Thomas et al.
The Histochemical journal, 26(3), 189-196 (1994-03-01)
Factors which influence the iron-stimulated lipid peroxidation in rat liver have been studied by incubating unfixed cryostat sections with a pro-oxidant system and using an optimized histochemical detection method for lipid peroxidation products with 3-hydroxy-2-naphthoic acid hydrazide and Fast Blue
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