Skip to Content
Merck
All Photos(1)

Documents

Safety Information

544280

Sigma-Aldrich

2,5-Dichlorothiophene-3-sulfonyl chloride

97%

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C4HCl3O2S2
CAS Number:
56946-83-9
Molecular Weight:
251.54
MDL number:
MFCD00051665
UNSPSC Code:
12352100
PubChem Substance ID:
24878722
NACRES:
NA.22

Assay

97%

refractive index

n20/D 1.595 (lit.)

bp

256-257 °C (lit.)

density

1.697 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

Clc1cc(c(Cl)s1)S(Cl)(=O)=O

InChI

1S/C4HCl3O2S2/c5-3-1-2(4(6)10-3)11(7,8)9/h1H

InChI key

JJKSHSHZJOWSEC-UHFFFAOYSA-N

General description

2,5-Dichlorothiophene-3-sulfonyl chloride is an heteroaryl sulfonyl chloride derivative.

Application

2,5-Dichlorothiophene-3-sulfonyl chloride may be used in the preparation of:
  • 1-[(2,5-dichloro-3-thienyl)sulfonyl]-N-(6-nitro-1,3-benzothiazol-2-yl)piperidine-4-carboxamide
  • 6-chloro-3-isopropylamino-4H-thieno[2,3-e]-1,2,4-thiadiazine 1,1-dioxide
  • 6-fluoro-3-methyl-4-(2,5-dichlorothiophene-3-sulfonyl)-3,4-dihydroquinoxalin-2-(1H)-one

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

230.0 °F - closed cup

Flash Point(C)

110 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 3 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

544280-BULK:
544280-5G:
544280-VAR:
544280-1G:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Flemming E Nielsen et al.
Journal of medicinal chemistry, 49(14), 4127-4139 (2006-07-11)
Compound 1a (NN414) is a potent opener of Kir6.2/SUR1 K(ATP) channels. Compound 1a inhibits insulin release in vitro and in vivo and preserves beta cell function in preclinical animal models suggesting that such a compound could find use in treatment
Bailing Xu et al.
Bioorganic & medicinal chemistry, 17(7), 2767-2774 (2009-03-10)
A series of novel N(4)-(hetero)arylsulfonylquinoxalinone derivatives were prepared in a straight and efficient way. Of all the synthesized compounds, five compounds exhibited potent anti-HIV-1 replication activities with IC(50) value at the level of 10(-7) mol/L. Preliminary structure-activity relationships were studied
Synthesis, characterization, and anti-plasmodial activity of 2,6-substituted benzothiazole derivatives.
Sadhasivam G, et al.
Bangladesh Journal of Pharmacology, 11(2), 321-327 (2016)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service