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464139

Sigma-Aldrich

6-Methoxysalicylic acid

98%

Synonym(s):

2-Hydroxy-6-methoxybenzoic acid

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About This Item

Linear Formula:
CH3OC6H3(OH)CO2H
CAS Number:
3147-64-6
Molecular Weight:
168.15
MDL number:
MFCD00674090
UNSPSC Code:
12352100
PubChem Substance ID:
24870142
NACRES:
NA.22

Assay

98%

form

solid

mp

134-138 °C (lit.)

functional group

carboxylic acid

SMILES string

COc1cccc(O)c1C(O)=O

InChI

1S/C8H8O4/c1-12-6-4-2-3-5(9)7(6)8(10)11/h2-4,9H,1H3,(H,10,11)

InChI key

AAUQLHHARJUJEH-UHFFFAOYSA-N

General description

6-Methoxysalicylic acid has been reported to exhibit significant analgesic effects.

Application

6-Methoxysalicylic acid has been used to fabricate a dummy template molecule required for the preparation of dummy molecularly imprinted polymers (DMIPs). These polymers are useful for the simultaneous selective removal and enrichment of ginkgolic acids (GAs) during the processing of Ginkgo biloba leaves. It may be employed as internal standard for the determination of acetylsalicylic acid (aspirin, ASA) and its major metabolite, salicylic acid (SA), in animal plasma by LC/MS/MS.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

464139-1G:
464139-VAR:
464139-BULK:
4641390001:
464139-10G:

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Certificates of Analysis (COA)

Lot/Batch Number
MKBP9372V
MKAA3439V
MKAA3439
13522BH
10420DD

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Francisco Palacios-Espinosa et al.
Journal of ethnopharmacology, 118(3), 448-454 (2008-06-28)
Brickellia veronicifolia (Kunth) Gray (Asteraceae) (BV) is broadly commercialized for treating gastrointestinal diseases (stomach aches, biliary colics and dyspepsia), arthritis, diabetes and painful inflammatory complaints. In order to complete the preclinical pharmacological profile of BV, first the antinociceptive effect of
Xiangrong Xu et al.
Biomedical chromatography : BMC, 23(9), 973-979 (2009-04-10)
A simple and sensitive analytical method using liquid chromatography-tandem mass spectrometry (LC/MS/MS) for determination of acetylsalicylic acid (aspirin, ASA) and its major metabolite, salicylic acid (SA), in animal plasma has been developed and validated. Both ASA and SA in plasma
Ecem Evrim Çelik et al.
Food research international (Ottawa, Ont.), 108, 286-294 (2018-05-08)
The interactions of coffee and bread crust melanoidins with hydroxycinnamic and hydroxybenzoic acids (HCA/HBA) containing different numbers of -OH and -OCH₃ groups localized at different positions on the aromatic ring were investigated. By doing so, mechanism of the interactions was
Wenhua Ji et al.
Journal of chromatography. A, 1368, 44-51 (2014-12-03)
Dummy molecularly imprinted polymers (DMIPs) for simultaneously selective removal and enrichment of ginkgolic acids (GAs) during the processing of Ginkgo biloba leaves have been prepared. Two dummy template molecule with similar structural skeleton to GAs, 6-methoxysalicylic acid (MOSA, DT-1) and

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