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412422

Sigma-Aldrich

PAMAM dendrimer, ethylenediamine core, generation 3.0 solution

20 wt. % in methanol

Synonym(s):

Starburst PAMAM-G 3

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About This Item

Linear Formula:
[NH2(CH2)2NH2]:(G=3);dendri PAMAM(NH2)32
CAS Number:
153891-46-4
Molecular Weight:
6908.84
MDL number:
MFCD00197936
UNSPSC Code:
12162002
NACRES:
NA.23

description

amino surface groups

form

liquid

mol wt

generation 3.0

feature

core type ethylenediamine core (2-carbon core)

concentration

20 wt. % in methanol

no. Surface Groups

32

refractive index

n20/D 1.367

bp

64.7 °C

density

0.863 g/mL at 25 °C

storage temp.

2-8°C

General description

PAMAM dendrimer is a symmetrical polymer with a large number of terminal groups that can easily bind to biomolecules due to their biocompatibility and affinity. These dendrimers have a multivalent surface that contains envelopes and various active sites at the core with the attached dendrons. They are highly branched nanoscale polymers that are extensively used in the field of biomedicine for targeted drug delivery.

Application

PAMAM dendrimers can be used as transfection agents for the delivery of nucleic acids. For example, it can be used in the pulmonary delivery of siRNA directed against tumor necrosis factor (TNF).

Physical form

Contains 32 surface primary amino groups

Legal Information

Manufactured by Dendritech®, Inc.
Dendritech is a registered trademark of Dendritech, Inc.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

51.8 °F - closed cup

Flash Point(C)

11 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 1 petroleums
Hazardous rank II
Water insoluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

412422-2G:
412422-1G:
412422-5G:4548173147253
412422-BULK:
412422-25G:4548173147246
412422-VAR:

Certificates of Analysis (COA)

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Polyamidoamine dendrimers: Favorable polymeric nanomaterials for lipase activation
Amal A.M. Elgharbawy, et al.
Materials Today Communications, 25, 101492-101492 (2020)
Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-? siRNA with PAMAM dendrimers in a murine model
Adam Bohr, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 156, 114-120 (2020)
Ajay Vikram Singh et al.
ACS applied materials & interfaces, 13(1), 1943-1955 (2020-12-30)
In an in vitro nanotoxicity system, cell-nanoparticle (NP) interaction leads to the surface adsorption, uptake, and changes into nuclei/cell phenotype and chemistry, as an indicator of oxidative stress, genotoxicity, and carcinogenicity. Different types of nanomaterials and their chemical composition or

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