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408719

Sigma-Aldrich

Polyethylenimine, branched

average Mw ~800 by LS, average Mn ~600 by GPC

Synonym(s):

PEI, ethylenediamine branched

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About This Item

Linear Formula:
H(NHCH2CH2)nNH2
CAS Number:
25987-06-8
MDL number:
MFCD00084427
UNSPSC Code:
12162002
NACRES:
NA.23

form

viscous liquid

mol wt

average Mn ~600 by GPC
average Mw ~800 by LS

refractive index

n20/D 1.5240

density

1.050 g/mL at 25 °C

InChI

1S/C2H8N2.C2H5N/c3-1-2-4;1-2-3-1/h1-4H2;3H,1-2H2

InChI key

SFLOAOINZSFFAE-UHFFFAOYSA-N

Related Categories

General description

Polyethyleneimine is a hydrophilic polymerwidely used as a non-viral synthetic vector for invivo delivery of therapeutic nucleic acids. Owing to its excellentphysicochemical properties, it is applied in many fields like the separationand purification of proteins, carbon dioxide absorption, drug carriers,effluent treatment, and biological labels.

Application

Branched PEI can be used as a precursor to synthesize conjugated polyplexes for efficient gene transfection. Conjugation of PEI with Jeffamine polyether and guanidinylation of the amino groups of PEI reduce the cytotoxicity of the polyplexes and protect them from aggregation in the presence of serum proteins.

Bamboo charcoal impregnated with PEI can be used as a CO2 adsorbent. Numerous amino groups present in PEI can react with CO2 due to acid-alkali interaction and enhance the adsorption capacity of bamboo charcoal.

It can also be used to prepare cross-linked water-soluble polymers with high coordination capabilities towards organic drug molecules.

Features and Benefits

  • Branched PEI has better complexation and buffering capacity.
  • High ion exchange capacity and affinity toward proteins.
  • SignificantDNA transfer efficiency.

Physical form

Branched polymer

Signal Word

Danger

Hazard Statements

H302,H318,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

356.0 °F

Flash Point(C)

180 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 3 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

408719-100ML:
408719-BULK:
408719-VAR:
408719-250ML:
408719-1L:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Valentina Dinca et al.
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Insurmountable detection challenges will impede the development of many of the next-generation of lab-on-a-chip devices (e.g., point-of-care and real-time health monitors). Here we present the first membrane-based, microfluidic sample preconcentration method that is continuous, quantifiable, simple, and capable of working
Irena Mamajanov et al.
Life (Basel, Switzerland), 10(8) (2020-08-23)
Enzymes are biological catalysts that are comprised of small-molecule, metal, or cluster catalysts augmented by biopolymeric scaffolds. It is conceivable that early in chemical evolution, ancestral enzymes opted for simpler, easier to assemble scaffolds. Herein, we describe such possible protoenzymes:
Jonathon M Muncie et al.
Developmental cell, 55(6), 679-694 (2020-11-19)
Embryogenesis is directed by morphogens that induce differentiation within a defined tissue geometry. Tissue organization is mediated by cell-cell and cell-extracellular matrix (ECM) adhesions and is modulated by cell tension and tissue-level forces. Whether cell tension regulates development by modifying
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