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374334

Sigma-Aldrich

1,1,1,2-Tetrafluoroethane

≥99%

Synonym(s):

HFC-134a

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About This Item

Linear Formula:
FCH2CF3
CAS Number:
811-97-2
Molecular Weight:
102.03
EC Number:
212-377-0
MDL number:
MFCD00066608
UNSPSC Code:
12142100
PubChem Substance ID:
24863300
NACRES:
NA.22

Assay

≥99%

bp

−26.5 °C (lit.)

functional group

fluoro

SMILES string

FCC(F)(F)F

InChI

1S/C2H2F4/c3-1-2(4,5)6/h1H2

InChI key

LVGUZGTVOIAKKC-UHFFFAOYSA-N

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General description

1,1,1,2-Tetrafluoroethane is used as a trifluorovinylating agent in organic synthesis. It is identified as a potential refrigerant used in place of chlorofluorocarbons. 1,1,1,2-Tetrafluoroethane can also be used as a solvent and medical propellant for a wide range of applications. It is used to extract materials of natural origin like natural flavors, fragrances, and nutraceuticals.[1][2]

Application

1,1,1,2-Tetrafluoroethane can be used:
  • As a solvent in the preparation of cross-linked polymer microspheres through the dispersion polymerization method.[3]
  • As a porogenic solvent in the preparation of porous polymethacrylate monolith via free radical polymerization.[4]
  • In the synthesis of trifluorovinyllithium, a key intermediate for the preparation of 2-halo-2,3-dideoxy-arabinose derivatives of biological importance.[5]

Packaging

Supplied in a Sure/Pac™ cylinder and has a brass needle valve with a male 1/4" NPTF outlet thread installed. Before using the cylinder, ensure that the valve is closed, then remove the galvanized steel hex cap that seals the outlet valve.

Compatible with the following:

Legal Information

Aldrich is a registered trademark of Sigma-Aldrich Co. LLC
Sure/Pac is a trademark of Sigma-Aldrich Co. LLC

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Hose adapter, brass

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Pictograms

Gas cylinder
GHS04

Signal Word

Warning

Hazard Statements

H280

Precautionary Statements

P410 + P403

Hazard Classifications

Press. Gas Compr. Gas

Storage Class Code

2A - Gases

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

374334-VAR:
374334-100G:
374334-25G:
374334-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
SHBP7561
SHBM9829
SHBM5331
SHBK9275
SHBH4927V

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Synthesis of porous cross-linked polymer monoliths using 1, 1, 1, 2-tetrafluoroethane (R134a) as the porogen
Hebb AK, et al.
Composites Science and Technology, 63(16), 2379-2387 (2003)
P D Levin et al.
British journal of anaesthesia, 92(6), 865-869 (2004-05-04)
1,1,1,2 Tetrafluoroethane is a hydrofluoroalkane (HFA) that is replacing chlorofluorocarbons (CFC) as a medical aerosol propellant in an attempt to reduce damage to the ozone layer. This study compared the effects of HFA- and CFC-based inhalers on four anaesthetic gas
Yongwon Seo et al.
Environmental science & technology, 38(17), 4635-4639 (2004-10-06)
A new separation method using gas hydrate formation is proposed for separating HFC-134a from gas mixtures containing N2 and HFC-134a. The feasibility of this separation method was investigated from various points of view. First, to determine the mixed hydrate stability
1, 1, 1, 2-Tetrafluoroethane; from refrigerant and propellant to solvent
Corr S
Journal of Fluorine Chemistry, 118(1-2), 55-67 (2002)
Yang Chen et al.
Pharmaceutical research, 32(9), 2928-2936 (2015-03-20)
This study investigated the effect of different active pharmaceutical ingredients (API) on aerosol electrostatic charges and aerosol performances for pressurized metered dose inhalers (pMDIs), using both insulating and conducting actuators. Five solution-based pMDIs containing different API ingredients including: beclomethasone dipropionate
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