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Safety Information

362417

Sigma-Aldrich

4-Chloro-2-fluoro-5-nitrotoluene

98%

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About This Item

Linear Formula:
ClC6H2(F)(NO2)CH3
CAS Number:
18349-11-6
Molecular Weight:
189.57
EC Number:
242-225-9
MDL number:
MFCD00134231
UNSPSC Code:
12352100
PubChem Substance ID:
24862309
NACRES:
NA.22

Assay

98%

mp

42-45 °C (lit.)

SMILES string

Cc1cc(c(Cl)cc1F)[N+]([O-])=O

InChI

1S/C7H5ClFNO2/c1-4-2-7(10(11)12)5(8)3-6(4)9/h2-3H,1H3

InChI key

SJDPAVRCQNFVDM-UHFFFAOYSA-N

Application

4-Chloro-2-fluoro-5-nitrotoluene may be used in the synthesis of two new C-11 labeled analogs of N,N-dimethyl-2-(2′-amino-4′-hydroxymethyl-phenylthio)benzylamine, which were further evaluated as serotonin transporter imaging agents.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

362417-5G:
362417-VAR:
362417-1G:
362417-BULK:

Certificates of Analysis (COA)

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Nachwa Jarkas et al.
Nuclear medicine and biology, 37(5), 593-603 (2010-07-09)
Carbon-11 (C-11) N,N-dimethyl-2-(2'-amino-4'-hydroxymethyl-phenylthio)benzylamine ([(11)C]HOMADAM) has been reported as highly specific and selective positron emission tomography (PET) radiotracer showing fast kinetics for the human brain serotonin transporter (SERT). In our continued effort to develop appropriate PET SERT radioligand that can be

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