325090

Methyl (R)-(+)-3-bromo-2-methylpropionate

97%

• Synonym(s): (+)-Methyl (R)-β-bromoisobutyrate
• Linear Formula: BrCH₂CH(CH₃)CO₂CH₃
• CAS Number: 110556-33-7
• Molecular Weight: 181.03
• Beilstein: 1720833
• MDL number: MFCD00010639
• UNSPSC Code: 12352101
• PubChem Substance ID: 24859486
• NACRES: NA.22

Properties

• Assay: 97%
• form: liquid
• optical activity: [α]20/D +16°, neat
• optical purity: ee: 99% (GLC)
• refractive index: n20/D 1.455 (lit.)
• bp: 85 °C/37 mmHg (lit.)
• density: 1.422 g/mL at 25 °C (lit.)
• functional group: bromo; ester
• SMILES string: COC(=O)[C@@H](C)CBr
• InChI: 1S/C5H9BrO2/c1-4(3-6)5(7)8-2/h4H,3H2,1-2H3/t4-/m0/s1
• InChI key: FKWNAVCXZSQYTA-BYPYZUCNSA-N

Description

Application

Methyl (R)-(+)-3-bromo-2-methylpropionate can be used as a reactant to prepare:

• (S)-3-(6-Methoxy-pyridin-3-yl)-2-methylpropionic acid methylester by reacting with 5-bromo-2-methoxy pyridine via nucleophilic displacement reaction.
• Decahydroisoquinoline derivative (NVP-ACQ090) as a potent antagonist of somatostatin sst3 receptor.

It can also be used as a reference compound in the enantioselective alkylation reaction of hydrophobic vitamin B12 derivatives.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): 163.4 °F - closed cup
• Flash Point(C): 73 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves