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Safety Information

324817

Sigma-Aldrich

(Aminomethyl)phosphonic acid

99%

Synonym(s):

AMPA

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About This Item

Linear Formula:
NH2CH2P(O)(OH)2
CAS Number:
1066-51-9
Molecular Weight:
111.04
Beilstein:
1701219
MDL number:
MFCD00008105
UNSPSC Code:
12352100
PubChem Substance ID:
24859469
NACRES:
NA.22

Assay

99%

form

solid

solubility

water: soluble 50 mg/mL, clear, colorless

SMILES string

NCP(O)(O)=O

InChI

1S/CH6NO3P/c2-1-6(3,4)5/h1-2H2,(H2,3,4,5)

InChI key

MGRVRXRGTBOSHW-UHFFFAOYSA-N

Gene Information

human ... F10(2159) , F2(2147) , PLG(5340)
rat ... Gria1(50592) , Gria2(29627) , Gria3(29628) , Gria4(29629) , Grik1(29559) , Grik2(54257) , Grin2a(24409) , Grm1(24414) , Grm2(24415) , Grm4(24417) , Grm5(24418) , Slc1a1(25550) , Slc1a2(29482) , Slc1a3(29483)

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General description

(Aminomethyl)phosphonic acid is a metabolite of amitrole and glyphosate herbicides and was analyzed by HPLC using an electrochemical detector.

Application

(Aminomethyl)phosphonic acid was used to develop a novel kind of immobilized metal affinity chromatography column based on organic-inorganic hybrid silica monolith.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

324817-VAR:
324817-250MG:
324817-50G:
324817-BULK:
324817-1G:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Francisco Sánchez-Bayo et al.
Analytica chimica acta, 675(2), 125-131 (2010-08-31)
The herbicides amitrole and glyphosate, and its metabolite aminomethyl-phosphonic acid (AMPA), in water samples have been directly analysed by high-performance liquid chromatography using an electrochemical (EC) detector. Limits of detection of 0.3 microg mL(-1) for glyphosate, 0.05 microg mL(-1) for
Chunyan Hou et al.
Journal of proteome research, 9(8), 4093-4101 (2010-06-24)
A novel kind of immobilized metal affinity chromatography (IMAC) column based on organic-inorganic hybrid silica monolith has been developed. The monolithic support was prepared in a 250 microm i.d. capillary by the sol-gel method with tetraethoxysilane (TEOS) and 3-aminopropyltriethoxysilane (APTES)
M Tomita et al.
Journal of chromatography, 571(1-2), 324-330 (1991-11-15)
Capillary electrophoresis has been used to separate and quantitate glyphosate and its major metabolite, (aminomethyl)phosphonic acid (AMPA), in serum. The two compounds, after derivatization with p-toluenesulphonyl chloride, were clearly separated with 0.1 M boric acid-sodium hydroxide buffer (pH 9.6) containing
G M Williams et al.
Regulatory toxicology and pharmacology : RTP, 31(2 Pt 1), 117-165 (2000-06-15)
Reviews on the safety of glyphosate and Roundup herbicide that have been conducted by several regulatory agencies and scientific institutions worldwide have concluded that there is no indication of any human health concern. Nevertheless, questions regarding their safety are periodically
E Börjesson et al.
Journal of chromatography. A, 886(1-2), 207-216 (2000-08-19)
New methods were developed to determine glyphosate, N-(phosphonomethyl)glycine, and its major metabolite, (aminomethyl)phosphonic acid in groundwater and soil. The methods involve ligand-exchange, anion-exchange and derivatisation and final identification and quantification by GC-MS. The limits of quantification in this experiment were
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