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292087

Sigma-Aldrich

1-Chloro-2-propanol

70%

Synonym(s):

Chloropropanol, Propylene chlorohydrin

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25 G
¥6,100

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25 G
¥6,100

About This Item

Linear Formula:
CH3CH(OH)CH2Cl+CH3CHClCH2OH
CAS Number:
127-00-4
Molecular Weight:
94.54
Beilstein:
773653
EC Number:
204-819-6
MDL number:
MFCD00004530
UNSPSC Code:
12352100
PubChem Substance ID:
24857557
NACRES:
NA.22

¥6,100

List Price¥10,600Save 42%

Estimated to ship onApril 06, 2025

Request a Bulk Order

Quality Level

200

Assay

70%

impurities

<25% 2-chloro-1-propanol

refractive index

n20/D 1.439 (lit.)

bp

126-127 °C (lit.)

density

1.111 g/mL at 25 °C (lit.)

functional group

chloro
hydroxyl

SMILES string

CC(O)CCl

InChI

1S/C3H7ClO/c1-3(5)2-4/h3,5H,2H2,1H3

InChI key

YYTSGNJTASLUOY-UHFFFAOYSA-N

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General description

1-Chloro-2-propanol is formed as an intermediate during the degradation of meso-bis-(1-chloro-2-propyl)ether by Rhodococcus sp. strain DTB[1].

Application

1-Chloro-2-propanol has been used as:
  • chemical intermediate for the manufacture of propylene oxide, a starting material for production of polyurethane polyols and propylene glycol[2]
  • as α,β-halohydrin standard during the enzymatic synthesis of α,β-halohydrins from gaseous alkenes[3]

Pictograms

FlameSkull and crossbones
GHS02,GHS06

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

125.6 °F - closed cup

Flash Point(C)

52 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 2 petroleums
Hazardous rank III
Water soluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

292087-25G:4548173347622
292087-VAR:
292087-100G:
292087-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK7285
BCBR2116V
BCCK9074
BCBM2764V
BCBM0131V

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Leif-Alexander Garbe et al.
FEMS microbiology ecology, 55(1), 113-121 (2006-01-20)
Rhodococcus sp. strain DTB (DSM 44534) was grown on a mixture of (R,R)-, (S,S)- and meso-bis-(1-chloro-2-propyl) ether (BCPE) as the sole source of carbon and energy. During BCPE degradation 1'-chloro-2'-propyl-3-chloro-2-prop-1-enyl-ether (DVE), 1-chloro-2-propanol and chloroacetone intermediates were formed. The BCPE or
J Geigert et al.
Applied and environmental microbiology, 45(2), 366-374 (1983-02-01)
The enzymatic synthesis of alpha,beta-halohydrins from gaseous alkenes is described. The enzymatic reaction required an alkene, a halide ion, dilute hydrogen peroxide, and a haloperoxidase enzyme. A wide range of gaseous alkenes were suitable for this reaction, including those containing
Propylene chlorohydrins: toxicology, metabolism, and environmental fate.
R S Yang
Reviews of environmental contamination and toxicology, 99, 47-59 (1987-01-01)
J A Bond et al.
Toxicology and applied pharmacology, 95(3), 444-455 (1988-09-30)
Propylene chlorohydrins, of which 1-chloro-2-propanol (1-CP) is a constituent, used as intermediates in the manufacture of propylene oxide and have been identified as potential air pollutants. The objective of these studies was to determine whether changes in the inhaled exposure
R W Biles et al.
Fundamental and applied toxicology : official journal of the Society of Toxicology, 3(1), 27-33 (1983-01-01)
A 72:25 mixture of 1-chloro-2-propanol and 2-chloro-1-propanol was tested for genetic activity in a battery of short term tests. Chloropropanol was tested over a dose range of 527-167,250 micrograms/plate in the Salmonella/mammalian microsome mutagenicity assay. A dose dependent mutagenic response
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