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278858

Sigma-Aldrich

3-Iodo-4-methylbenzoic acid

97%

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About This Item

Linear Formula:
IC6H3(CH3)CO2H
CAS Number:
82998-57-0
Molecular Weight:
262.04
MDL number:
MFCD00010392
UNSPSC Code:
12352100
PubChem Substance ID:
24856837
NACRES:
NA.22

Assay

97%

form

solid

mp

210-212 °C (lit.)

SMILES string

Cc1ccc(cc1I)C(O)=O

InChI

1S/C8H7IO2/c1-5-2-3-6(8(10)11)4-7(5)9/h2-4H,1H3,(H,10,11)

InChI key

LDDHMKANNXWUAK-UHFFFAOYSA-N

Application

3-Iodo-4-methylbenzoic acid has been used in the preparation of:
  • unlabeled N-succinimidyl 4-guanidinomethyl-3-iodobenzoate (SGIMB)
  • boc-protected derivative of SGIMB (Boc-SGMIB)

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

278858-5G:4548173987552
278858-100G:
278858-VAR:
278858-25G:4548173987569
278858-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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G Vaidyanathan et al.
Bioconjugate chemistry, 12(3), 428-438 (2001-05-17)
The objective of this study was to develop an acylation agent for the radioiodination of monoclonal antibodies that would maximize retention of the label in tumor cells following receptor- or antigen-mediated internalization. The strategy taken was to add a polar
Ganesan Vaidyanathan et al.
Nature protocols, 2(2), 282-286 (2007-04-05)
This protocol describes a detailed procedure for the synthesis of N-succinimidyl 4-guanidinomethyl-3-[*I]iodobenzoate ([*I]SGMIB), an agent useful in the radio-iodination of proteins, including monoclonal Abs, and peptides that undergo internalization after receptor or antigen binding. In this procedure, the tin precursor

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