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264415

Sigma-Aldrich

2,4-Difluorobenzyl bromide

98%

Synonym(s):

α-Bromo-2,4-difluorotoluene

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About This Item

Linear Formula:
F2C6H3CH2Br
CAS Number:
23915-07-3
Molecular Weight:
207.02
EC Number:
245-938-3
MDL number:
MFCD00011649
UNSPSC Code:
12352100
PubChem Substance ID:
24856014
NACRES:
NA.22

Assay

98%

form

liquid

refractive index

n20/D 1.525 (lit.)

density

1.613 g/mL at 25 °C (lit.)

SMILES string

Fc1ccc(CBr)c(F)c1

InChI

1S/C7H5BrF2/c8-4-5-1-2-6(9)3-7(5)10/h1-3H,4H2

InChI key

IBLMYGXJKQIGSN-UHFFFAOYSA-N

Application

2,4-Difluorobenzyl bromide has been used in the preparation of:
  • novel 1,2,4-triazolium derivatives
  • 1,5-biaryl pyrrole EP1 receptor antagonists

Signal Word

Danger

Hazard Statements

H226,H314,H317,H334

Hazard Classifications

Flam. Liq. 3 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

104.0 °F - closed cup

Flash Point(C)

40 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 2 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

264415-5G:
264415-25G:
264415-VAR:
264415-BULK:

Certificates of Analysis (COA)

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Adrian Hall et al.
Bioorganic & medicinal chemistry letters, 16(14), 3657-3662 (2006-05-16)
The preliminary SAR of a series of novel 1,5-biaryl pyrrole EP1 receptor antagonists derived from compound 1 is described. Replacement of the benzyl group of 1 with isosteric groups was investigated. The most effective replacement was found to be the
Yan Luo et al.
Archiv der Pharmazie, 342(7), 386-393 (2009-06-23)
A series of novel 1,2,4-triazolium derivatives was synthesized starting from commercially available 1H-1,2,4-triazole, 2,4-dichlorobenzyl chloride, or 2,4-difluorobenzyl bromide. Their antibacterial and antifungal activities were evaluated against Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Bacillus proteus, Bacillus subtilis, Pseudomonas aeruginosa

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