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Safety Information

218693

Sigma-Aldrich

1-Aminocyclohexanecarboxylic acid

98%

Synonym(s):

Homocycloleucine

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About This Item

Linear Formula:
H2NC6H10CO2H
CAS Number:
2756-85-6
Molecular Weight:
143.18
Beilstein:
2355692
EC Number:
220-411-0
MDL number:
MFCD00001487
UNSPSC Code:
12352106
PubChem Substance ID:
24853079
NACRES:
NA.22

Assay

98%

form

solid

reaction suitability

reaction type: solution phase peptide synthesis

mp

>300 °C (lit.)

application(s)

peptide synthesis

SMILES string

NC1(CCCCC1)C(O)=O

InChI

1S/C7H13NO2/c8-7(6(9)10)4-2-1-3-5-7/h1-5,8H2,(H,9,10)

InChI key

WOXWUZCRWJWTRT-UHFFFAOYSA-N

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

218693-1G:
218693-BULK:
218693-5G:
218693-25G:
218693-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG3282
BCCF6625
BCCD7125
BCBM3524V
BCBJ4719V

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A Romanelli et al.
Journal of peptide science : an official publication of the European Peptide Society, 7(1), 15-26 (2001-03-14)
Secondary structure formation and stability are essential features in the knowledge of complex folding topology of biomolecules. To better understand the relationships between preferred conformations and functional properties of beta-homo-amino acids, the synthesis and conformational characterization by X-ray diffraction analysis
B L Shulkin et al.
Journal of neurochemistry, 64(3), 1252-1257 (1995-03-01)
The delivery of large neutral amino acids (LNAAs) to brain across the blood-brain barrier (BBB) is mediated by the L-type neutral amino acid transporter present in the membranes of the brain capillary endothelial cell. In experimental animals, the L-system transporter
Wioleta Kowalczyk et al.
Journal of medicinal chemistry, 47(24), 6020-6024 (2004-11-13)
The synthesis and some pharmacological properties of two sets of analogues, one consisting of six peptides with 1-aminocyclohexane-1-carboxylic acid (Acc) in position 2 and the other with the amino acid in position 3, have been described. All the peptides were
Mitsunobu Doi et al.
Biochemical and biophysical research communications, 297(1), 138-142 (2002-09-11)
Endomorphin (EM2, Tyr-Pro-Phe-Phe-NH(2)) can assume various conformations related to cis/trans-rotamers of the amide linkage of Tyr-Pro. To control isomerization, restricted or flexible components have been introduced at the Pro position. We focused on [Chx(2)]EM2, an EM2 analogue substituting 1-aminocyclohexane-1-carboxlylic acid
Olga Labudda-Dawidowska et al.
Journal of medicinal chemistry, 48(25), 8055-8059 (2005-12-13)
In the present work, a sterically constrained noncoded amino acid, 1-aminocyclohexane-1-carboxylic acid (Acc), was substituted in position 8 of the peptide chain of bradykinin (BK) and position 6, 7, or 8 of its B2 receptor antagonist [D-Arg0,Hyp3,Thi,(5,8)D-Phe7]BK, previously synthesized by
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