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Safety Information

190616

Sigma-Aldrich

2-Hydroxy-3-nitropyridine

98%

Synonym(s):

3-Nitro-2-pyridinol, 3-Nitro-2-pyridone

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About This Item

Empirical Formula (Hill Notation):
C5H4N2O3
CAS Number:
6332-56-5
Molecular Weight:
140.10
Beilstein:
124474
EC Number:
228-709-2
MDL number:
MFCD00006270
UNSPSC Code:
12352100
PubChem Substance ID:
24851450
NACRES:
NA.22

Assay

98%

mp

212 °C (dec.) (lit.)

SMILES string

Oc1ncccc1[N+]([O-])=O

InChI

1S/C5H4N2O3/c8-5-4(7(9)10)2-1-3-6-5/h1-3H,(H,6,8)

InChI key

BOAFCICMVMFLIT-UHFFFAOYSA-N

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General description

2-Hydroxy-3-nitropyridine reacts with phosphorus pentachloride and phosphoryl chloride to yield 2-chloro-3-nitropyridine.

Application

2-Hydroxy-3-nitropyridine was used in the synthesis of:
  • 3-nitro-2-pyridyl β-D-galactoside
  • 3-nitro-2-pyridyl N-acetyl-β-D-glucosaminide
  • 5-amino-6-chloro-3-iodopyridine

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

190616-5G:
190616-VAR:
190616-25G:
190616-1KG:
190616-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
02528TW
S26748
09521LN
08624KF
04706JV

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Nanjing Zhang et al.
Bioorganic & medicinal chemistry letters, 13(3), 525-527 (2003-02-05)
Racemic 5-azidoepibatidine [(+/-)-1] was synthesized via 5-aminoepibatidine as a candidate photoaffinity ligand with exceptionally high affinity at the mammalian neuronal nicotinic receptors (K(i) values of 0.027 nM for alpha 4 beta 2 and 9.7 nM for alpha 7) and excellent
Nitropyridyl glycosides: new glycosyl donors for enzymatic transglycosylation.
Yasukochi T, et al.
Tetrahedron Letters, 40(36), 6585-6589 (1999)
85. Nucleophilic displacement reactions in aromatic systems. Part I. Kinetics of the reactions of chloronitropyridines with aromatic amines and with pyridine.
Bishop RR, et al.
Journal of the Chemical Society, 437-446 (1952)

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