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178950

Sigma-Aldrich

Methanesulfonyl fluoride

98%

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About This Item

Linear Formula:
CH3SO2F
CAS Number:
558-25-8
Molecular Weight:
98.10
EC Number:
209-192-2
MDL number:
MFCD00007423
UNSPSC Code:
12352100
PubChem Substance ID:
24850783

Assay

98%

reaction suitability

reaction type: click chemistry

bp

123-124 °C (lit.)

density

1.427 g/mL at 25 °C (lit.)

SMILES string

CS(F)(=O)=O

InChI

1S/CH3FO2S/c1-5(2,3)4/h1H3

InChI key

KNWQLFOXPQZGPX-UHFFFAOYSA-N

General description

Methanesulfonyl fluoride is an anticholinesterase (antiChEs), used to treat Alzheimer′s disease. It is a thrombin inhibitor.

accessory

Product No.
Description
Pricing

Pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

Signal Word

Danger

Hazard Statements

H300 + H330,H314

Hazard Classifications

Acute Tox. 2 Oral - Skin Corr. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

178950-50G:
178950-VAR:
178950-BULK:
178950-25G:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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D H Malin et al.
Neurobiology of aging, 12(2), 181-183 (1991-03-01)
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P Masson et al.
Biochimica et biophysica acta, 869(3), 304-313 (1986-02-14)
In order to determine whether a structural modification at the active center of cholinesterase may alter the conformational stability of the enzyme we compared the urea-induced unfolding of the tetrameric form of non-inhibited and irreversibly inhibited human plasma cholinesterase (acylcholine
M Zorko et al.
Biochemical pharmacology, 35(14), 2287-2296 (1986-07-15)
The binding of D-tubocurarine (TC) to acetylcholinesterase (AChE) was studied using different methods of enzyme kinetics. The main results are as follows. TC reversibly inhibits the hydrolysis of different substrates of AChE with three different inhibition constants (Ki1 = 7.0
R Panenic et al.
Journal of applied physiology (Bethesda, Md. : 1985), 87(4), 1455-1462 (1999-10-12)
The purpose of this study was to investigate the functional impact of acute irreversible inhibition of acetylcholinesterase (AChE) on the fatigability of medial gastrocnemius and plantaris muscles of Sprague-Dawley rats. After treatment with methanesulfonyl fluoride (a lipid-soluble anticholinesterase), which reduced
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