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162531

Sigma-Aldrich

3-Fluorobenzoyl chloride

98%

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About This Item

Linear Formula:
FC6H4COCl
CAS Number:
1711-07-5
Molecular Weight:
158.56
Beilstein:
636610
EC Number:
216-977-3
MDL number:
MFCD00000670
UNSPSC Code:
12352100
PubChem Substance ID:
24849988
NACRES:
NA.22

Assay

98%

form

liquid

refractive index

n20/D 1.529 (lit.)

bp

189 °C (lit.)

mp

−30 °C (lit.)

density

1.304 g/mL at 25 °C (lit.)

SMILES string

Fc1cccc(c1)C(Cl)=O

InChI

1S/C7H4ClFO/c8-7(10)5-2-1-3-6(9)4-5/h1-4H

InChI key

SYVNVEGIRVXRQH-UHFFFAOYSA-N

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Application

3-Fluorobenzoyl chloride was used in synthesis of 4-[18F]fluoro-N-[2-[1-(2-methoxyphenyl)-1-piperazinyl]ethyl-N-2-pyridinyl-benzamide by radiosynthesis. It was also used as reagent in one-pot synthesis of N-(1,3-diphenyl-1H-pyrazol-5-yl)amides. It was used in three phase hollow fiber liquid-phase microextraction with in situ derivatization method coupled with HPLC-UV for the determination of metformin hydrochloride in biological fluids.

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

179.6 °F - closed cup

Flash Point(C)

82 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 3 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

162531-25G:
162531-VAR:
162531-BULK:
162531-5G:
162531-100G:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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An efficient one-pot synthesis of N-(1, 3-diphenyl-1H-pyrazol-5-yl) amides.
Su W-N, et al.
Journal of Heterocyclic Chemistry, 47(4), 831-837 (2010)
D Le Bars et al.
Nuclear medicine and biology, 25(4), 343-350 (1998-06-25)
No-carrier-added 4-[18F]fluoro-N-[2-[1-(2-methoxyphenyl)-1 piperazinyl]ethyl-N-2-pyridinyl-benzamide (p-[18F]MPPF) was synthesized by nucleophilic substitution of the corresponding nitro compound in the presence of Kryptofix 222 and K2CO3 by microwave heating (3 min, 500 W) using a remotely controlled radiosynthesis. Baseline separation of p-[18F]MPPF from the
Gazala Mohamed Ben-Hander et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 941, 123-130 (2013-11-10)
A three phase hollow fiber liquid-phase microextraction with in situ derivatization (in situ HF-LPME) followed by high-performance liquid chromatography-ultraviolet detection (HPLC-UV) method was developed for the trace determination of metformin hydrochloride (MH) in biological fluids. A new derivatization agent pentafluorobenzoyl
Dima A Sabbah et al.
Medicinal chemistry (Shariqah (United Arab Emirates)), 15(4), 417-429 (2018-09-13)
Phosphoinositide 3-kinase α (PI3Kα) has emerged as a promising target for anticancer drug design. Target compounds were designed to investigate the effect of the p-OCH3 motifs on ligand/PI3Kα complex interaction and antiproliferative activity. Synthesis of the proposed compounds, biological examination

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