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162493

Sigma-Aldrich

4-Fluorobenzylamine

97%

Synonym(s):

(4-Fluorophenyl)methanamine, 1-(4-Fluorophenyl)methanamine, 4-Fluorobenzenemethanamine, [(4-Fluorophenyl)methyl]amine, p-Fluorobenzylamine

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About This Item

Linear Formula:
FC6H4CH2NH2
CAS Number:
140-75-0
Molecular Weight:
125.14
Beilstein:
636501
EC Number:
205-430-4
MDL number:
MFCD00008120
UNSPSC Code:
12352100
eCl@ss:
39040409
PubChem Substance ID:
24849984
NACRES:
NA.22

Assay

97%

form

liquid

refractive index

n20/D 1.512 (lit.)

bp

183 °C (lit.)

density

1.095 g/mL at 25 °C (lit.)

SMILES string

NCc1ccc(F)cc1

InChI

1S/C7H8FN/c8-7-3-1-6(5-9)2-4-7/h1-4H,5,9H2

InChI key

IIFVWLUQBAIPMJ-UHFFFAOYSA-N

Gene Information

human ... AOC3(8639)
mouse ... Aoc3(11754)

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General description

[18F]4-fluorobenzylamine reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate. It is an important building block for the synthesis of 18F-labeled compounds.

Application

4-Fluorobenzylamine was used in the synthesis of new tris-iron(III) chelates of 3-hydroxy-4-pyridinone ligands.

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H290,H314

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

150.8 °F - closed cup

Flash Point(C)

66 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 2 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

162493-25G:
162493-BULK:
162493-5G:
162493-1G:
162493-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ingrid Koslowsky et al.
Organic & biomolecular chemistry, 8(20), 4730-4735 (2010-08-27)
A novel synthesis of 4-[(18)F]fluorobenzylamine ([(18)F]FBA) by means of transition metal-assisted sodium borohydride reduction of 4-[(18)F]fluorobenzonitrile ([(18)F]FBN) is described. This approach could successfully be extended to borohydride exchange resin (BER) enabling a viable option for use in automated syntheses. [(18)F]FBA
T Haradahira et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 49(12), 1551-1556 (1998-09-24)
A fluorine-18 labeled analog of an antitumor prostaglandin delta 7-PGA1 methyl ester, 15-deoxy-13,14-dihydro-delta 7-PGA1 4-[18F]fluorobenzyl amide ([18F]3), was synthesized as a tracer candidate for detecting tumors with positron emission tomography. p-[18F]Fluorobenzylamine (p-[18F]FBnA) used as a labeled precursor for the synthesis
3'-Aza-2'-[18F]fluorofolic acid.
Leung K
SourceMolecular Imaging and Contrast Agent Database (MICAD) [Internet] (2013)
Walkiria Schlindwein et al.
Dalton transactions (Cambridge, England : 2003), (10)(10), 1313-1321 (2006-03-01)
New tris-iron(III) chelates of 3-hydroxy-4-pyridinone ligands derived from maltol (3-hydroxy-2-methyl-4-pyrone) or ethylmaltol (2-ethyl-3-hydroxy-4-pyrone), including a variety of N-aryl (phenyl, 4'-tolyl, 4'-(n-butyl)phenyl, 4'-(n-hexyl)phenyl) and N-benzyl (4'-methylbenzyl, 4'-fluorobenzyl and 4'-(trifluoromethyl)benzylamine) substituents on the nitrogen atom of the pyridinone ring, have been prepared.
Muhammad Kaleem Khosa et al.
Pakistan journal of pharmaceutical sciences, 28(6), 2167-2171 (2015-12-08)
New series of benzophenone imines with general formula Ph2-C=NR; R = Benzyl, 4-Fluorobenzyl, Naphthyl, Phenyl, 4-Nitrophenyl were synthesized by condensation of dichlorodiphenylmethane and different aromatic primary amines (1:1) Those imines were characterized by different physiochemical and spectroscopic techniques like melting
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