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142824

Sigma-Aldrich

1-Methyl-1-cyclohexanecarboxylic acid

99%

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About This Item

Linear Formula:
CH3C6H10CO2H
CAS Number:
1123-25-7
Molecular Weight:
142.20
EC Number:
214-371-3
MDL number:
MFCD00001463
UNSPSC Code:
12352100
PubChem Substance ID:
24848538
NACRES:
NA.22

Assay

99%

form

solid

bp

234 °C (lit.)

mp

36-39 °C (lit.)

SMILES string

CC1(CCCCC1)C(O)=O

InChI

1S/C8H14O2/c1-8(7(9)10)5-3-2-4-6-8/h2-6H2,1H3,(H,9,10)

InChI key

REHQLKUNRPCYEW-UHFFFAOYSA-N

Related Categories

General description

1-Methyl-1-cyclohexanecarboxylic acid is the structural analog of valproic acid and its pharmacokinetic action has been studied in female Sprague-Dawley rats.

Application

1-Methyl-1-cyclohexanecarboxylic acid was used as internal standard during the determination of valproic acid metabolites.

Biochem/physiol Actions

1-Methyl-1-cyclohexanecarboxylic acid is an anticonvulsant drug and causes maturation of murine neuroblastoma cells in vitro.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

213.8 °F - closed cup

Flash Point(C)

101.00 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

142824-1G:
142824-10G:
142824-VAR:
142824-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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V P Poluianov
Sudebno-meditsinskaia ekspertiza, 35(1), 31-32 (1992-01-01)
Method of extraction-atomic absorption detection of arsenic in biologic material using naphthenic acid was developed and tested. Method can be used for arsenic detection in postmortem material. It differs from the known method by its accuracy, reliability and simple use.
Effects of 1-methyl cyclohexane carboxylic acid (CCA) on cellular energetics in neuroblastoma cells.
B Croizat et al.
Biochemical and biophysical research communications, 103(3), 1044-1051 (1981-12-15)
J L Vayssière et al.
FEBS letters, 173(1), 19-22 (1984-07-23)
Various mitochondrial inhibitors are tested in neuroblastoma cells. Their effects on the mit-proteins and some cytoskeletal proteins are compared to those of CCA, a differentiation inducer. This comparison favours the hypothesis that the primary effect of CCA induction is an
J L Vayssière et al.
Biochemical and biophysical research communications, 120(2), 411-419 (1984-04-30)
The evolution of three major mit-proteins was followed in neuroblastoma cells cultured in different conditions of differentiation. 1 methyl cyclohexane carboxylic acid (CCA) was found to stimulate the synthesis of the three mit-protein markers. This result, compared to the effects
S A Fischkoff et al.
Journal of biological response modifiers, 3(2), 132-137 (1984-01-01)
The anticonvulsant drug 1-methyl-1-cyclohexanecarboxylic acid ( MCCA ) has been shown to cause maturation of murine neuroblastoma cells in vitro at concentrations that are pharmacologically achievable. HL-60 human promyelocytic leukemia cells cultured with this drug underwent a dose-dependent decrease in
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