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Safety Information

122912

Sigma-Aldrich

2-Amino-6,8-dihydroxypurine

Synonym(s):

2-Amino-6,8-purinediol, 8-Hydroxyguanine

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About This Item

Empirical Formula (Hill Notation):
C5H5N5O2
CAS Number:
5614-64-2
Molecular Weight:
167.13
EC Number:
227-035-6
MDL number:
MFCD00005564
UNSPSC Code:
12352200
PubChem Substance ID:
329749690

impurities

<10% acetic acid

SMILES string

Nc1nc(O)c2[nH]c(O)nc2n1

InChI

1S/C5H5N5O2/c6-4-8-2-1(3(11)10-4)7-5(12)9-2/h(H5,6,7,8,9,10,11,12)

InChI key

CLGFIVUFZRGQRP-UHFFFAOYSA-N

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

122912-BULK:
122912-10G:
122912-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
14125MG
08206EG
02717JZ
02302AZ
01701JZ

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Ilinca Nicolae et al.
Experimental and therapeutic medicine, 17(2), 1012-1019 (2019-01-27)
Recent data suggest that severe psoriasis is an independent risk factor for chronic renal disease. In the present study, we investigated the role of related-purine derivatives as predictors of renal dysfunctions in patients with psoriasis. A prospective study was conducted
Jia Guo et al.
Nucleic acids research, 41(16), 7700-7712 (2013-06-19)
Oxidized bases in DNA have been implicated in cancer, aging and neurodegenerative disease. We have developed an approach combining single-cell gel electrophoresis (comet) with fluorescence in situ hybridization (FISH) that enables the comparative quantification of low, physiologically relevant levels of
Ana-Maria Chiorcea-Paquim et al.
Mikrochimica acta, 188(2), 58-58 (2021-01-29)
Oxidative DNA damage plays an important role in the pathogenesis of various diseases. Among oxidative DNA lesions, 8-oxoguanine (8-oxoG) and its corresponding nucleotide 8-oxo-2'-deoxyguanosine (8-oxodG), the guanine and deoxyguanosine oxidation products, have gained much attention, being considered biomarkers for oxidative
Sara Timpano et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(4), 5716-5728 (2019-01-17)
Multicellular organisms balance oxygen delivery and toxicity by having oxygen pass through several barriers before cellular delivery. In human cell culture, these physiologic barriers are removed, exposing cells to higher oxygen levels. Human cells cultured in ambient air may appear
Eleonora Parlanti et al.
Free radical biology & medicine, 53(11), 2171-2177 (2012-09-27)
Although oxidatively damaged DNA is repaired primarily via the base excision repair (BER) pathway, it is now evident that multiple subpathways are needed. Yet, their relative contributions and coordination are still unclear. Here, mouse embryo fibroblasts (MEFs) from selected nucleotide
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