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12255

Sigma-Aldrich

1,2-Benzisoxazole

≥95.0%

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About This Item

Empirical Formula (Hill Notation):
C7H5NO
CAS Number:
271-95-4
Molecular Weight:
119.12
Beilstein:
2154
EC Number:
205-983-1
MDL number:
MFCD00005852
UNSPSC Code:
12352100
PubChem Substance ID:
24847495
NACRES:
NA.22

Assay

≥95.0%

refractive index

n20/D 1.561 (lit.)
n20/D 1.563

bp

90-92 °C/15 mmHg (lit.)

density

1.174 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

c1ccc2oncc2c1

InChI

1S/C7H5NO/c1-2-4-7-6(3-1)5-8-9-7/h1-5H

InChI key

KTZQTRPPVKQPFO-UHFFFAOYSA-N

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General description

1,2-Benzisoxazole derivative zonisamide is a novel antiepileptic drug and is effective for the treatment of partial seizures. 1,2-Benzisoxazole is a potential substrates of rabbit liver aldehyde oxidase.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

186.8 °F - closed cup

Flash Point(C)

86 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 3 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

12255-BULK-F:
12255-25ML-F:
12255-VAR-F:
12255-5ML-F:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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D H Peters et al.
Drugs, 45(5), 760-787 (1993-05-01)
Zonisamide is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug. It has shown activity in various animal models of epilepsy, and although a detailed mode of action awaits clarification
Nan-Sook Hong et al.
Nature communications, 9(1), 3900-3900 (2018-09-27)
Developments in computational chemistry, bioinformatics, and laboratory evolution have facilitated the de novo design and catalytic optimization of enzymes. Besides creating useful catalysts, the generation and iterative improvement of designed enzymes can provide valuable insight into the interplay between the
W Gristwood et al.
Xenobiotica; the fate of foreign compounds in biological systems, 18(8), 949-954 (1988-08-01)
1. Twelve oxygen and sulphur azaheterocycles were studied as potential substrates of rabbit liver aldehyde oxidase. Only benzoxazole and 1,2-benzisoxazole were found to be substrates. 2. Nine of the compounds inhibited the oxidation of quinazoline by aldehyde oxidase and in
Min Bao et al.
International journal of biological macromolecules, 137, 537-544 (2019-06-25)
Studies on endo-inulinases from yeast are scarce, compared to those from other microbial sources. In this study, a novel endo-inulinase from Lipomyces starkeyi NRRL Y-11557 was identified, expressed in its soluble form, and characterized its physicochemically properties, together with its
Avneet Kaur et al.
Archiv der Pharmazie, 351(6), e1800008-e1800008 (2018-05-10)
A series of N-(2-(3,5-dimethoxyphenyl)benzoxazole-5-yl)benzamide derivatives (3am) was synthesized and evaluated for their in vitro inhibitory activity against COX-1 and COX-2. The compounds with considerable in vitro activity (IC50  < 1 μM) were evaluated in vivo for their anti-inflammatory potential by the carrageenan-induced
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