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105538

Sigma-Aldrich

7-Chloro-4-hydroxyquinoline

99%

Synonym(s):

7-Chloro-4-quinolinol

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About This Item

Empirical Formula (Hill Notation):
C9H6ClNO
CAS Number:
86-99-7
Molecular Weight:
179.60
EC Number:
201-715-2
MDL number:
MFCD00006778
UNSPSC Code:
12352100
PubChem Substance ID:
24846703

Assay

99%

mp

276-279 °C (lit.)

SMILES string

Oc1ccnc2cc(Cl)ccc12

General description

7-Chloro-4-hydroxyquinoline is formed by the reaction of 4,7-dichloroquinoline with glacial acetic acid in anhydrous medium.

Biochem/physiol Actions

7-Chloro-4-hydroxyquinoline is an antitumor drug.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

105538-25G:
105538-BULK:
105538-100G:
105538-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sigma-Aldrich

H0915

Hydroxychloroquine sulfate

The reaction of 4, 7-dichloroquinoline with acetic acid.
Cutler RA and Surrey AR.
Journal of the American Chemical Society, 72(8), 3394-3395 (1950)
Chloroquine metabolism in man: urinary excretion of 7-chloro-4-hydroxyquinoline and 7-chloro-4-aminoquinoline metabolites.
N D Brown et al.
Journal of chromatography, 345(1), 209-214 (1985-11-29)
Antioxidative or prooxidative effect of 4-hydroxyquinoline derivatives on free-radical-initiated hemolysis of erythrocytes is due to its distributive status.
Liu ZQ, et al.
Biochim. Biophys. Acta Gen. Subj., 1570(2), 97-103 (2002)

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