SML3411

LY2828360

≥98% (HPLC)

• Synonym(s): 8-(2-Chlorophenyl)-2-methyl-6-(4-methyl-1-piperazinyl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine, LY 2828360
• Empirical Formula (Hill Notation): C₂₂H₂₇ClN₆O
• CAS Number: 1231220-79-3
• Molecular Weight: 426.94
• MDL number: MFCD28010855
• UNSPSC Code: 41121800
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: -10 to -25°C
• SMILES string: Clc1c(cccc1)c2[n](c4nc(nc(c4n2)N5CCN(CC5)C)C)C3CCOCC3
• InChI: 1S/C22H27ClN6O/c1-15-24-21(28-11-9-27(2)10-12-28)19-22(25-15)29(16-7-13-30-14-8-16)20(26-19)17-5-3-4-6-18(17)23/h3-6,16H,7-14H2,1-2H3
• InChI key: UCMNDPDJRSEZPL-UHFFFAOYSA-N

Description

Biochem/physiol Actions

LY2828360 is a potent and selective slowly acting G protein-biased CB2 cannabinoid agonist that inhibits cAMP accumulation and activates ERK1/2 signaling while failing to recruit arrestin. LY2828360 suppress chemotherapy-induced neuropathic pain created by paclitaxel without producing tolerance in mice.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable