SML1736

Nelarabine

≥98% (HPLC)

• Synonym(s): 2-amino-9-β-D-arabinofuranosyl-6-methoxy-9H-purine, 506U, 506U78, 9-β-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine, Arranon, Atriance, GW-506U78
• Empirical Formula (Hill Notation): C₁₁H₁₅N₅O₅
• CAS Number: 121032-29-9
• Molecular Weight: 297.27
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: O[C@@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C=NC3=C2N=C(N)N=C3OC
• InChI: 1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10?/m1/s1
• InChI key: IXOXBSCIXZEQEQ-KBNQYOMWSA-N

Description

Biochem/physiol Actions

Antineoplastic purine nucleoside analog used in T-cell acute lymphoblastic leukemia; pro-drug of Ara-G.

Nelarabine is an antineoplastic purine nucleoside analog used in T-cell acute lymphoblastic leukemia. It is a pro-drug of Ara-G, which is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. Incorporation of Ara-GTP into DNA leads to inhibition of DNA synthesis and apoptosis.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable