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S3672

Sigma-Aldrich

[Sar9, Met(O2)11]-Substance P

≥95% (HPLC)

Synonym(s):

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met[O2]-NH2

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About This Item

Empirical Formula (Hill Notation):
C64H100N18O15S
CAS Number:
110880-55-2
Molecular Weight:
1393.66
MDL number:
MFCD00076787
UNSPSC Code:
12352209
PubChem Substance ID:
24899567
NACRES:
NA.32

Assay

≥95% (HPLC)

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)CN(C)C(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(N)CCCNC(N)=N)C(=O)NC(CCS(C)(=O)=O)C(N)=O

InChI

1S/C64H100N18O15S/c1-38(2)34-46(57(89)74-42(54(69)86)28-33-98(4,96)97)73-53(85)37-80(3)62(94)48(36-40-18-9-6-10-19-40)79-58(90)47(35-39-16-7-5-8-17-39)78-56(88)43(24-26-51(67)83)75-55(87)44(25-27-52(68)84)76-59(91)50-23-15-32-82(50)63(95)45(21-11-12-29-65)77-60(92)49-22-14-31-81(49)61(93)41(66)20-13-30-72-64(70)71/h5-10,16-19,38,41-50H,11-15,20-37,65-66H2,1-4H3,(H2,67,83)(H2,68,84)(H2,69,86)(H,73,85)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,88)(H,79,90)(H4,70,71,72)

InChI key

OUPXSLGGCPUZJJ-UHFFFAOYSA-N

Gene Information

human ... TACR1(6869)
mouse ... TACR1(21336)
rat ... TACR1(24807)

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Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met[O]2-NH2

Biochem/physiol Actions

Highly selective NK-1 receptor agonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Distribution of Fos-like immunoreactivity in guinea-pig brain following administration of the neurokinin-1 receptor agonist[SAR9MET(O2)11]substance.
Yip, J., et al.
P. Neuroscience, 94, 663-673 (1999)
Frank Cloutier et al.
British journal of pharmacology, 148(1), 25-38 (2006-02-24)
1 Effects of intrathecally (i.t.) injected tachykinin NK-1 and -3 receptor agonists and antagonists were measured on mean arterial blood pressure (MAP) and heart rate (HR) in awake unrestrained spontaneously hypertensive rats (SHR,15-week-old) and age-matched Wistar Kyoto rats (WKY). Quantitative
Wen-Ling Chen et al.
Biochemical and biophysical research communications, 339(1), 132-136 (2005-11-23)
Neurokinin-1 receptor (NK-1) plays an important role in nociception. The present study was to explore whether activation of peripheral NK-1 receptor, especially expressed on primary sensory afferents, could induce hyperalgesia and sensitize C-type sensory afferents. (1) Intraplantar administration of NK-1
Takayuki Endoh
Brain research, 1110(1), 116-127 (2006-07-29)
Neurokinins, such as substance P (SP), modulate the reflex regulation of cardiovascular and respiratory function in the CNS, particularly in the nucleus tractus solitarius (NTS). There is considerable evidence of the action of SP in the NTS, but the precise
Arvind K Chappa et al.
Pharmaceutical research, 23(6), 1201-1208 (2006-05-27)
Substance P (SP; NH3(+)-Arg(+)-Pro-Lys(+)-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2) belongs to a group of neurokinins that are widely distributed in the central nervous system and peripheral nervous system. The biological effects mediated by SP in the central nervous system include regulation of affective behavior, emesis
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