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P3495

Sigma-Aldrich

Phrixotoxin-2

>98% (HPLC), lyophilized powder

Synonym(s):

κ-TRTX-Ps1b, PaTX2

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About This Item

MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

>98% (HPLC)

form

lyophilized powder

mol wt

3921 Da

storage temp.

−20°C

Amino Acid Sequence

Tyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Glu-Glu-Arg-Lys-Cys-Cys-Glu-Gly-Leu-Val-Cys-Arg-Leu-Trp-Cys-Lys-Arg-Ile-Ile-Asn-Met

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ryan C Smith et al.
Reproductive biology and endocrinology : RB&E, 5, 41-41 (2007-11-06)
Uterine smooth muscle cells exhibit ionic currents that appear to be important in the control of uterine contractility, but how these currents might produce the changes in contractile activity seen in pregnant myometrium has not been established. There are conflicting
S Diochot et al.
British journal of pharmacology, 126(1), 251-263 (1999-03-02)
1. In the present study, two new peptides, phrixotoxins PaTx1 and PaTx2 (29-31 amino acids), which potently block A-type potassium currents, have been purified from the venom of the tarantula Phrixotrichus auratus. 2. Phrixotoxins specifically block Kv4.3 and Kv4.2 currents
Natalie J Saez et al.
Toxins, 2(12), 2851-2871 (2011-11-10)
Spiders are the most successful venomous animals and the most abundant terrestrial predators. Their remarkable success is due in large part to their ingenious exploitation of silk and the evolution of pharmacologically complex venoms that ensure rapid subjugation of prey.

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