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P3252

Sigma-Aldrich

6-Phenyl-2-thiouracil

≥95%

Synonym(s):

2-Mercapto-6-phenyl pyrimidine-4-ol, 6-Phenylthiouracil, Fenucil

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About This Item

Empirical Formula (Hill Notation):
C10H8N2OS
CAS Number:
36822-11-4
Molecular Weight:
204.25
EC Number:
253-227-4
MDL number:
MFCD00059166
UNSPSC Code:
41106305
PubChem Substance ID:
24897877
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

100

Assay

≥95%

form

powder

solubility

DMF: 20 mg/mL, clear to slightly hazy, colorless to light yellow

SMILES string

Oc1cc(nc(S)n1)-c2ccccc2

InChI

1S/C10H8N2OS/c13-9-6-8(11-10(14)12-9)7-4-2-1-3-5-7/h1-6H,(H2,11,12,13,14)

InChI key

XEKNACRTWJHOCE-UHFFFAOYSA-N

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Application

6-Phenyl-2-thiouracil is a thyreostatic (thyroid hormone) agent that may be used as a reference material in thyreostatic drug separation and detection technologies such as capillary electrophoresis, HPLC, or gas chromatography.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S Abuín et al.
Analytica chimica acta, 617(1-2), 184-191 (2008-05-20)
A method based on ultra-performance liquid chromatography-electrospray ionisation-tandem mass spectrometry for the determination of six thyreostatic drugs in thyroid tissue has been optimised and validated in accordance with the Decision 2002/657/EC. Samples are extracted with methanol and the extracts cleaned-up
Dexian Kong et al.
Electrophoresis, 30(19), 3489-3495 (2009-09-04)
A simple, rapid, reproducible and sensitive method based on CE with electrochemical detector was developed for the simultaneous determination of five thyreostatics including 2-thiouracil (TU), 6-methyl-2-thiouracil (MTU), 6-propyl-2-thiouracil (PTU), 6-phenyl-2-thiouracil (PhTU) and methimazole (TAP) in animal feeds. A home-made wall-jet
R Schilt et al.
Journal of chromatography, 489(1), 127-137 (1989-04-07)
Methods are described for the screening and confirmation of residues of the thyreostatics thiouracil, methylthiouracil and propylthiouracil in urine samples of cattle at levels down to 25 micrograms/l. After a selective preconcentration of the thiol-containing thyreostatics on a mercurated affinity
Highly potent and selective inhibition of HIV-1 replication by 6-phenylthiouracil derivatives.
M Baba et al.
Antiviral research, 17(4), 245-264 (1992-04-01)
Tomás Pérez-Ruiz et al.
Electrophoresis, 26(12), 2384-2390 (2005-05-17)
This paper reports the development of a method based on capillary electrophoresis with laser-induced fluorescence detection for the simultaneous determination of thiouracil (TU) and phenylthiouracil (PhTU) with high sensitivity (nanomolar range, i.e., attomoles detected). After derivatization with 5-iodoacetamidofluorescein, the analytes
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