I7784

Anti-Interleukin-2 antibody produced in goat

affinity isolated antibody, lyophilized powder

• Synonym(s): Anti-IL-2
• MDL number: MFCD00675261
• UNSPSC Code: 51111800
• NACRES: NA.41

Properties

• biological source: goat
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: rat, mouse
• technique(s): neutralization: suitable; western blot: 0.1-0.2 μg/mL
• UniProt accession no.: P04351
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: mouse ... Il2(16183) ; rat ... Il2(116562)

Description

General description

Interleukin-2 (IL-2) is a cytokine produced by activated T cells in response to antigen stimulation. IL-2 is important for proliferation of lymphocytes, natural killer cells and macrophages and in the differentiation of CD4⁺ cells into Th1 and Th2 effector cells. The effects of IL-2 are mediated by the signalling activated by its binding to IL-2 receptor (IL-2 R). IL-2 activates key signalling pathways such as MAPK, JAK/STAT as well as PI3K/Akt. Activation of these pathways modulates production of inflammatory cytokines, survival and progression through cell cycle
Monoclonal Anti-Interleukin-2 recognizes murine Interleukin-2. It does not react with human IL-2, but will react with rabbit IL-2 at a 100x higher IgG concentration.

Immunogen

purified, E. coli-derived recombinant mouse interleukin-2.

Application

Anti-interleukin-2 antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. The antibody is suitable for murine IL-2 neutralization assays.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves