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Key Documents

700025P

Avanti

7β,27-dihydroxycholesterol

Avanti Research - A Croda Brand

Synonym(s):

(3β,7β,25R)-Cholest-5-ene-3,7,26-triol

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About This Item

Empirical Formula (Hill Notation):
C27H46O3
CAS Number:
Molecular Weight:
418.65
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 1 mg (700025P-1mg)

manufacturer/tradename

Avanti Research - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=C[C@@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC[C@@H](C)CO

General description

7β,27-dihydroxycholesterol is a substrate for enzyme 11β-hydroxysteroid dehydrogenases (11β-HSDs).

Application

7β,27-dihydroxycholesterol has been used as an internal standard in ultra-performance liquid chromatography -tandem mass spectrometer (UPLC-MS/MS). It has also been used as a substrate for 11β-hydroxysteroid dehydrogenases (11β-HSDs) in human embryonic kidney cells (HEK293).

Biochem/physiol Actions

7β,27-dihydroxycholesterol (7β27OHC) is a retinoid-related orphan receptor γ (RORγ) ligand. 7β27OHC favors smoothened (Smo) functionality.

Packaging

5 mL Amber Glass Screw Cap Vial (700025P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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11beta-Hydroxysteroid dehydrogenases control access of 7beta, 27-dihydroxycholesterol to retinoid-related orphan receptor gamma
Beck KR, et al.
Journal of Lipid Research, 60(9), 1535-1546 (2019)
Assessment of Altered Cholesterol Homeostasis by Xenobiotics Using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry
Herron J, et al.
Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (editor-in-chief) ... [Et al.], 78(1), e65-e65 (2018)

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