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Key Documents

900655

Sigma-Aldrich

Methoxy poly(ethylene glycol)-b-poly(L-lactide)

2k-5k

Synonym(s):

mPEG-b-PLA, mPEG-PLA, mPEG-PLLA

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About This Item

Linear Formula:
HO[CH(CH3)COO]m[CH2CH2O]nCH3
UNSPSC Code:
12162002
NACRES:
NA.23

Quality Level

form

powder

storage temp.

2-8°C

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Application

Biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic poly(L-lactide) (PLLA) block. These materials have been used in control release and nanoparticle formulation for drug encapsulation and delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Injectable biodegradable polymeric system for preserving the active form and delayed-release of camptothecin anticancer drugs.
Mert O, et al.
Royal Society of Chemistry Advances, 2(1), 176-185 (2012)
Zhigang Xie et al.
Journal of biomedical materials research. Part A, 88(1), 238-245 (2008-02-21)
Docetaxel (DX) is one of the most effective antineoplastic drugs. Its current clinical administration is limited because of its hydrophobicity and serious side effects. A polymer/DX conjugate is designed and successfully prepared to solve these problems. It is monomethoxy-poly(ethylene glycol)-block-poly(L-lactide)/DX

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