T0251

Thymidine 5′-triphosphate sodium salt

≥96%

• Synonym(s): TTP, dTTP
• Empirical Formula (Hill Notation): C₁₀H₁₆N₂O₁₄P₃Na
• CAS Number: 18423-43-3
• Molecular Weight: 504.15
• MDL number: MFCD00080338
• UNSPSC Code: 41106305
• PubChem Substance ID: 24899873
• NACRES: NA.51

Properties

• Quality Level: 200
• Assay: ≥96%
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [NaH].[P](=O)(O[P](=O)(OCC1OC(CC1O)N2C=C(C(=O)NC2=O)C)O)(O[P](=O)(O)O)O
• InChI: 1S/C10H17N2O14P3.Na.H/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18;;/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18);;
• InChI key: KAELIXTVSANDSE-UHFFFAOYSA-N

Description

Application

Thymidine 5′-triphosphate (dTTP) is one of the four natural deoxynucleotides, along with deoxyadenosine 5′-triphosphate (dATP), deoxyguanosine 5′-triphosphate (dGTP) and deoxycytosine 5′-triphosphate (dCTP) used for the biosynthesis of deoxyribonucleic acids by DNA polymerases and reverse transcriptases. Deoxy-TTP may also be used as a substrate to study the specificity and kinetics of thymidine-triphosphatase(s) (EC 3.6.1.39) and other dTTP hydrolyzing activities.

Thymidine 5′-triphosphate sodium salt has been used:

• in the quenching ability test for dual-aptamer and multiple-nucleotide detection based on a multiple-aptamer/GO-nS complex
• to study protein-metabolite interactions in the central metabolism of Escherichia coli
• in a polymerase chain reaction (PCR) product formation using AM-toxin primers

Biochem/physiol Actions

Thymidine triphosphate is a building block of DNA. It acts as an allosteric regulator of other nucleotides′ metabolism.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable