SML2299
Photoregulin3
≥98% (HPLC)
Synonym(s):
2-[(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)methyl]-6,7-dimethoxy-4(3H)-quinazolinone, PR3
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About This Item
Empirical Formula (Hill Notation):
C22H23N3O3
CAS Number:
Molecular Weight:
377.44
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
OC(C1=C2)=NC(CN3CCC(C4=CC=CC=C4)=CC3)=NC1=CC(OC)=C2OC
Biochem/physiol Actions
Photoregulin3 is a modulator of the rod transcription factor Nr2e3 that inhibits rod photoreceptor gene expression. Photoregulin3 significantly rescues photoreceptor in RhoP23H mice.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus.
Navickas, et al.
Nature Cell Biology (2023)
Paul A Nakamura et al.
eLife, 6 (2017-11-18)
Regulation of rod gene expression has emerged as a potential therapeutic strategy to treat retinal degenerative diseases like retinitis pigmentosa (RP). We previously reported on a small molecule modulator of the rod transcription factor Nr2e3, Photoregulin1 (PR1), that regulates the
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