SML2230

Nuciferine

≥98% (HPLC)

• Synonym(s): (-)-Nuciferine, (6aR)-5,6,6a,7-Tetrahydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline, (R)-1,2-Dimethoxyaporphine, (R)-Nuciferine, 1,2-Dimethoxy-6a-aporphine, D-(-)-Nuciferine, Nuciferin, Sanjoinine E, 1,2-Dimethoxy 6aβ-aporphine
• Empirical Formula (Hill Notation): C₁₉H₂₁NO₂
• CAS Number: 475-83-2
• Molecular Weight: 295.38
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD01664592
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• biological source: Nelumbo nucifera
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -145 to -165°, c = 0.5 in ethanol
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: [H][C@]1(C2=C3C(OC)=C(OC)C=C2CCN1C)CC4=C3C=CC=C4
• InChI: 1S/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1
• InChI key: ORJVQPIHKOARKV-OAHLLOKOSA-N

Description

Biochem/physiol Actions

Nuciferine is a major active component from lotus leaf that produces antipsychotic-like effect in rodents. Nuciferine is a potent inverse agonist at human 5-HT7 receptor. Nuciferine attenuates fructose-induced hyperuricemia, dyslipidemia and systemic inflammation in rats.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable