Yes, SBR00035-1ML can be used for the creation of a calibration curve to quantify SCFAs in stool samples. 1mL is enough for 64 stool samples because GC uses low injection volumes of 1-2μL. It can also be used for checking system suitability to make sure the GC instrument is preforming well.
SBR00035
13C-Short Chain Fatty Acids Stool Mixture
Suitable for mass spectrometry
Synonym(s):
SCFA, Sodium acetate-13C2, Sodium butyrate-13C4, Sodium propionate-13C3, Stool
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About This Item
UNSPSC Code:
12352211
NACRES:
NA.25
Pricing and availability is not currently available.
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General description
Short chain fatty acids (SCFAs) are saturated fatty acids with less than 6 carbons. SCFAs are produced in the gut by microbial fermentation of dietary fibers.[1] The most important and researched SCFAs are Acetate (Ac), propionate (Pr) and butyrate (Bu).[2] SCFAs are predominantly found in the colon and cross the intestinal epithelium to the blood stream. SCFAs were found to be beneficial and effective in prevention of obesity, Non-alcoholic fatty liver disease and insulin resistance.[3][4]
The concentration of SCFAs in Stool is varied from subject to subject in dependence to the experiment parameters. The Average concentration for Acetate, Propionate and Butyrate 30, 10, 10 μM respectively.
13C-SCFAs can serve in various applications:
The concentration of SCFAs in Stool is varied from subject to subject in dependence to the experiment parameters. The Average concentration for Acetate, Propionate and Butyrate 30, 10, 10 μM respectively.
13C-SCFAs can serve in various applications:
- spiking the mixture to track sample preparation errors.
- QC sample, to exclude run to run variations and to normalize the runs.
- Calibration curve to quantify SCFAs in Stool samples.
Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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J H Cummings et al.
Gut, 28(10), 1221-1227 (1987-10-01)
Evidence for the occurrence of microbial breakdown of carbohydrate in the human colon has been sought by measuring short chain fatty acid (SCFA) concentrations in the contents of all regions of the large intestine and in portal, hepatic and peripheral
Emanuel E Canfora et al.
Nature reviews. Endocrinology, 15(5), 261-273 (2019-01-24)
Evidence is accumulating that the gut microbiome is involved in the aetiology of obesity and obesity-related complications such as nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes mellitus (T2DM). The gut microbiota is able to ferment indigestible
Ara Koh et al.
Cell, 165(6), 1332-1345 (2016-06-04)
A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially
Tara M Henagan et al.
British journal of pharmacology, 172(11), 2782-2798 (2015-01-07)
Sodium butyrate (NaB), an epigenetic modifier, is effective in promoting insulin sensitivity. The specific genomic loci and mechanisms underlying epigenetically induced obesity and insulin resistance and the targets of NaB are not fully understood. The anti-diabetic and anti-obesity effects of
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Hi, can this be used to calibrate the GC machine? Is 1ml enough for 64 fecal samples? Is this suitable for rats fecal samples?
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