G1895

Gly-Pro-Arg-Pro

≥95% (HPLC)

• Synonym(s): GPRP, Glycyl-Prolyl-Arginyl-Proline amide
• Empirical Formula (Hill Notation): C₁₈H₃₁N₇O₅
• CAS Number: 67869-62-9
• Molecular Weight: 425.48
• MDL number: MFCD00133378
• UNSPSC Code: 12352209
• PubChem Substance ID: 24894914
• NACRES: NA.32

Properties

• Quality Level: 200
• Assay: ≥95% (HPLC)
• UniProt accession no.: P02751; P04937; P11276
• storage temp.: −20°C
• SMILES string: NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(O)=O
• InChI: 1S/C18H31N7O5/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22)/t11-,12-,13-/m0/s1
• InChI key: WXPZDDCNKXMOMC-AVGNSLFASA-N
• Gene Information: human ... FN1(2335) ; mouse ... FN1(14268) ; rat ... FN1(25661)

Description

Amino Acid Sequence

Gly-Pro-Arg-Pro

General description

Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the α chain of fibrin protein.

Application

Gly-Pro-Arg-Pro (GPRP) has been used for the formation of crystal composed of GPRP and the 30kDa C-terminal fragment from the γ chain of fibrinogen (rFbgγC30), cloned and expressed in Pichia pastoris.

Biochem/physiol Actions

Gly-Pro-Arg-Pro (GPRP) is capable of increasing free thrombin. Thus it can be utilized to make thrombin-degranulated platelets, which helps in studying platelet reactions.

Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis (β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid).

Inhibits fibrin polymerization.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves