85558

Spermidine

BioUltra, Molecular Biology, ≥99.5% (GC)

• Synonym(s): SPD, 1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
• Linear Formula: NH₂(CH₂)₃NH(CH₂)₄NH₂
• CAS Number: 124-20-9
• Molecular Weight: 145.25
• UNSPSC Code: 12352116
• NACRES: NA.26
• PubChem Substance ID: 57653053
• EC Number: 204-689-0
• Beilstein/REAXYS Number: 1698591
• MDL number: MFCD00008229
• Assay: ≥99.5% (GC)

Properties

• grade: Molecular Biology
• Quality Segment: 200
• product line: BioUltra
• assay: ≥99.5% (GC)
• storage condition: (Tightly closed. Keep locked up or in an area accessible only to qualified or authorizedpersons.)
• technique(s): ChIP: suitable, buffer exchange: suitable
• impurities: DNases, none detected, RNases, none detected, insoluble matter, passes filter test, phosphatases, none detected, proteases, none detected
• refractive index: n20/D 1.479 (lit.)
• pH: 12.0-13.5 (25 °C, 1 M in H₂O)
• solubility: H₂O: 1 M at 20 °C, clear, colorless
• density: 0.925 g/mL at 25 °C (lit.)
• anion traces: chloride (Cl^-): ≤50 mg/kg, sulfate (SO₄^2-): ≤50 mg/kg
• cation traces: Al: ≤5 mg/kg, As: ≤0.1 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg
• λ: 1 M in H₂O
• SMILES string: NCCCCNCCCN
• UV absorption: λ: 260 nm A_max: 0.1, λ: 280 nm A_max: 0.05
• suitability: suitable for molecular biology
• application(s): advanced drug delivery; genomic analysis
• InChI: 1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
• InChI key: ATHGHQPFGPMSJY-UHFFFAOYSA-N
• Gene Information: rat ... Ppm1a(24666)

Description

General description

Spermidine is a polyamine and a trivalent organic cation.Spermidine is a naturally occurring polyamine compound with diverse biochemical properties. It plays a vital role in gene expression, participating in DNA replication, transcription, and translation processes. Spermidine is crucial for cell growth, proliferation, and differentiation, influencing cell cycle progression and tissue development. It possesses antioxidant activity, safeguarding cells against oxidative stress by scavenging free radicals. Spermidine also stimulates autophagy, promoting the turnover of damaged organelles and protein aggregates for cellular homeostasis. With neuroprotective effects, it supports neuronal survival, synaptic plasticity, and guards against neurodegenerative diseases. Additionally, spermidine modulates cellular signaling pathways involved in inflammation and immune responses.

Application

Spermidine has been used:

• as a component of chromosome isolation buffer
• as a component of transcription buffer
• as a component of homogenization buffer

Biochem/physiol Actions

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T₄ polynucleotide kinase activity.

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T₄ polynucleotide kinase activity.

Spermidine modulates various cellular activities like cellular growth and development, stability of DNA and apoptosis.

Features and Benefits

• Versatile and adaptable for a wide variety of laboratory and research applications
• Suitable for Molecular Biology and Biochemical research
• Free from DNase, RNase, NICKase, and protease
• Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications
• Tested for trace levels of Anions and Cations

Analysis Note

liquid or solid

Other Notes

In first strand cDNA synthesis; Effect on endonuclease inhibition by agarose contaminants

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Disclaimer

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Codes: H314
• Precautionary Statements: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• Flash Point (°F): 233.6 °F - closed cup
• Flash Point (°C): 112 °C - closed cup
• PPE (personal protective equipment): Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter